glomerulonepritis

Question 1

what is glomerulonephritis?

Answer 1

inflammation of the glomerulus

basically damage to the glomerulus with blood and protein in urine

Question 2

what causes acute glomerulonephritis?

Answer 2

antibody/antigen complexes trapped
antigen is usually strep
sore throat followed by oliguria, haematuria, hypertension and slightly abnormal renal function

Question 3

who gets minimal change?

Answer 3

kids

Question 4

main symptom of minimal change?

Answer 4

proteinuria, but haematuria may also be present

Question 5

how do they majority present with minimal change?

Answer 5

nephrotic syndrome

Question 6

what would a biopsy of minimal change look like under microscope?

Answer 6

basically normal hence name

Question 7

what is the main tx of minimal change?

Answer 7

steroids (prednisolone)

Question 8

IgA nephropathy what is it also known as?

Answer 8

bergers disease

Question 9

in mergers disease you get deposition of IgA in?

Answer 9

mesangial cells

Question 10

typical presentation of bergers?

Answer 10

young man with haematuria a few days after a UTI/pharyngitis

Question 11

most aggressive glomerulonephritis?

Answer 11

rapidly progressive

Question 12

what appearance do you get of the glomeruli in rapidly progressive

Answer 12

crescent shaped appearance

Question 13

what causes crescent shaped appearance?

Answer 13

proliferation of macrophages and parietal epitelial cells in bowmans capsule

Question 14

treatment of rapidly progressive

Answer 14

immunosuppression (cyclosporin, cyclophosphamide)