Glomerulonephritis - Post-Streptococcal Glomerulonephritis

Question 1

What is Post-Streptococcal Glomerulonephritis?

Answer 1

Diffuse Proliferative Glomerulonephritis.

Question 2

Epidemiology of Post-Streptococcal Glomerulonephritis (2).

Answer 2

1. Below 30.

2. Full Recovery.

Question 3

Aetiology of Post-Streptococcal Glomerulonephritis.

Answer 3

7-14 Days following a Group A Beta-Haemolytic Streptococcus Infection e.g. S. pyogenes.

Question 4

Pathophysiology of Post-Streptococcal Glomerulonephritis.

Answer 4

Immune Complex - IgG, IgM, C3 deposition in the glomeruli.

Question 5

Clinical Features of Post-Streptococcal Glomerulonephritis (4).

Answer 5

1. Headache and Malise.
2. Visible Haematuria.
3. Proteinuria & Oedema.
4. Oliguria.

Question 6

Nephrotic or Nephritic Nature of Post-Streptococcal Glomerulonephritis.

Answer 6

Nephritic Syndrome.

Question 7

Investigations of Post-Streptococcal Glomerulonephritis (3).

Answer 7

1. Bloods : Low C3 and Raised ASO.
2. Electron Microscopy : Subepithelial ‘Humps’ - Immune Complex Deposits.
3. Immunofluorescence : Granular/Starry Sky Appearance.

Question 8

Management of Post-Streptococcal Glomerulonephritis.

Answer 8

Supportive - good prognosis.