Glomerulonephritis Flashcards
How does nephritic syndrome present?
haematuria
hypertension
oligouria
oedema
How does nephrotic syndrome present?
proteinuria
peripheral oedema
dyslipidaemia
hypoalbuminaemia
What is the pathology of nephritic syndrome?
it is an acute glomerulonephritis where damage to endothelium/ mesangial cells causes proliferative changes
What is the pathology of nephrotic syndrome?
damage to podocytes causes protein loss
How does goodpasture’s present?
haemoptysis + haematuria
What causes goodpasture’s?
anti-GBM antibodies
What is another name for henoch schonlein purpura?
IgA vasculitis
How does henoch schonlein purpura present?
abdominal pain
joint pain
rash
haematuria
What causes henoch schonlein purpura?
small vessel vasculitis occuring after URTI infection
How does IgA nephropathy present?
frank haematuria days after URTI
How does post-strep GN present?
nephritic syndrome 1-3 weeks following strep infection
What causes acute tubular necrosis?
sepsis
shock
rhabdomyolysis
What causes acute interstitial nephritis?
drug allergy eg NSAIDS diuretics PPIs antibiotics
What are the two causes of haemoptysis + haematuria ?
goodpasture’s
granulomatosis with polyangitis
How can you distinguish GPA from goodpastures?
goodpastures = lung + kidney
GPA also affects ENT –> epistaxis, sinusitis and fx of vasculits like joint pain, purpura
