Glomeruler Disease 5

Question 1

What is another name for membranoproliferazive GN Type 1 and 2?

Answer 1

mesagnio capillary GN

Question 2

How can Membranoproliferative GN be characterized histologically?

Answer 2

a. alterations in BM thickening

b. proliferation of glomerular cells

c. mild leukocyte infiltration

Question 3

Be able to reproduce this slide.

Answer 3

Reproduce slide.

Question 4

Describe C3 in in Type 1 membrano proliferative GN.

Answer 4

normal levels

Question 5

Does Type 1 MPGN activate the classical or alternate pathway of MPGN?

Answer 5

activation of classical pathway

low C1q, C4

Question 6

IF/EM features of Type 1 MPGN.

Answer 6

subendothelial granular deposits of IgG

Question 7

Prognosis of Type 1 IgG.

Answer 7

bad

Question 8

Type 2 MPGN C3 levels.

Answer 8

persistently low

Question 9

Properidin and factor B levels MPGN type II.

Answer 9

decreased

Question 10

What is the autoantibody in MPGN Type II?

Answer 10

C3 NeF auto to alternate pathway C3 convertase

Question 11

Prognosis for Type II MPGN?

Answer 11

the worst

Question 12

LM findings MPGN

Answer 12

Glomeruli: large hypercellular and lobulated

Mesangial, endothelial proliferation

Leukocytic infiltration

Increased mesangial matrix

Thickening of the Basement Membrane

Splitting of BM – double layer BM / ‘Tram Track’ appearance ( PASM)
–mesangial cells get interposed into GBM > GBM appears split.

Question 13

What type of stain is this and what is happening. Name the possible condition.

Answer 13

PASM ( periodic acid silver methamine)

Basement membrane splitting due to mesangial cell interposition

MPGN

Question 14

Type 2 MPGN EM characteristic features?

Answer 14

Dark electron dense deposits within the basement membrane seen as a ribbon- like mass – nature of the deposit not known

Question 15

What are the subendothelial deposits that can be seen upon IF in a person with MPGN Type 1?

Answer 15

IgG, C1q, C4

Question 16

T/F. MPGN follows a slowly progressive but unremitting course.

Answer 16

True

Question 17

Is there a response to steroids of those with MPGN?

Answer 17

no response to steroids

Question 18

C/F of chronic GN?

Answer 18

CRF; dialysis dependent

Question 19

Describe histology of those with chronic GN.

Answer 19

hyaline obliteration of glomeruli ;arterial and arteriolar sclerosis; marked atrophy of associated tubules.

Question 20

What are all the causes that can lead to Chonic GN. Create flow diagram.

Answer 20

Question 21

Another name for Chronic GN?

Answer 21

end stage kidney disease