Glomerular Disease

Question 1

1. ) Asymptomatic hema/proteinuria: protein/24 hours?
2. ) Acute nephritic: Inflammation?
3. ) RPGN: Usually more severe version of?
4. ) Nephrotic syndrome: Protein? Albumin? Immmunoglob? AT3? Lipids?
   - Azotemia? Oliguria?

Answer 1

• > 150mg/24 hours
• Yes
• Acute nephritic
• Low, low, low, low, high
• High Cr and BUN;

Question 2

1. ) MCD: Most common in? Assoc with? Responds to? EM?
2. ) FSGS: Common in? Related to? (3) EM? Type of injury?
3. ) MN: Common in? Assoc with? (4) Path? EM? IF? Treatment?
4. ) MPGN: Can also be? 2 types? Causes? IF?
5. ) DM: Due to sugars on? More common on? Treatment? Nodules?
6. ) Amyloidoses: Deposit where?

Answer 2

1. ) Kids; Hogkins; Steroids; Foot effacement
2. ) AA adults; HIV, heroine, drugs, sickle cell; same as MC; hyperfiltration
3. ) Caucasian adults; lupus, HBV, HCV, drugs; BM thickening, sub epi deposits; IgG and C3 GBM; steroids
4. ) Nephritic; 1.) Subendo = HBV, HCV 2.) Intramem = C3 nephritic factor
5. ) vascular BM; efferent; ACE-I; Kimmelsteil-Wilson
6. ) Mesengium

Question 3

1. ) IgA nephropathy: IgA deposits where? Present when?
2. ) Post infectious: Post what usually? EM? IF? Treatment?
3. ) RPGN: Shape? Linear? Granular? None? C-ANCA? P-ANCA? Do not treat with?
4. ) Alport Syndrome: Splitting of? Presents with? (2)

Answer 3

1. ) Mesangium; Childhood
2. ) Strep; Subepi deposits, Granular GBM for C3 and IgG; supportive
3. ) Crescent; Good pasture; PSGN, DPGN; Pauci; Wegners, Churg Strauss or MPA; steroids
4. ) GBM; hearing loss, occular involvement