GLOBULAR PROTEINS

Question 1

Group of specialized proteins that contain heme as a tightly bound prosthetic group.

Answer 1

GLOBULAR HEMEPROTEINS

Question 2

a hemeprotein present in heart and skeletal muscle functions both as a reservoir for oxygen and as an oxygen carrier that increases the rate of transport of oxygen within the muscle cell.

Answer 2

Myoglobin

Question 3

STRUCTURE OF HEME

Answer 3

protoporphyrin IX and ferrous iron (Fe2+)

Question 4

the major hemoglobin in adults, is composed of four polypeptide chains (two 𝛂 chains and two ꞵ chains) held together by noncovalent interactions.

Answer 4

Hemoglobin A,

Question 5

is the arrangement of multiple protein subunits into a functional unit.
highest level of protein structure.

Answer 5

QUATERNARY STRUCTURE OF HEMOGLOBIN

Question 6

This protein carries oxygen in the blood. It is made up of four subunits, two each of the alpha and beta types.

Answer 6

Hemoglobin

Question 7

This enzyme synthesizes new strands of DNA. It is made up of ten subunits.

Answer 7

DNA polymerase:

Question 8

These organelles are responsible for protein synthesis. They are made up of multiple protein subunits and RNA molecules.

Answer 8

Ribosomes

Question 9

These proteins help the body fight infection. They are made up of two identical heavy chains and two identical light chains

Answer 9

Antibodies

Question 10

is a plot of Y measured at different partial pressures of oxygen (pO2).

Answer 10

Oxygen-dissociation curve:

Question 11

are changes in the activity of a protein caused by the binding of a molecule to a site other than the active site.

Answer 11

ALLOSTERIC EFFECT

Question 12

responsible for the cooperative binding of oxygen.

Answer 12

Heme–heme interactions:

Question 13

phenomenon where the affinity of HgB to oxygen is inversely related to the concentration of co2

Answer 13

bohr effect

Question 14

is an important regulator of the binding of oxygen to hemoglobin.

is synthesized from an intermediate of the glycolytic pathway.

Answer 14

2,3- Bisphosphoglycerate (2,3-BPG)

Question 15

indicates that hemoglobin has a higher affinity for oxygen.

Answer 15

shift to the left

Question 16

indicates that hemoglobin has a lower affinity for oxygen

Answer 16

shift to the right i

Question 17

is normally synthesized only during fetal development.

is a tetramer consisting of two α chains plus two γ chains (α2γ2).

Answer 17

Fetal hemoglobin (HbF)

Question 18

are synthesized in the adult, although at low levels compared with HbA.

: is a minor component of normal adult hemoglobin, first appearing shortly before birth and, ultimately, constituting about 2% of the total hemoglobin. It is composed of two α-globin chains and two δ-globin chains (α2δ2)

Answer 18

Hemoglobin A2:

Question 19

is the most abundant form of glycosylated hemoglobin. Increased amounts of HbA1c are found in RBC of patients with diabetes mellitus,

Answer 19

Hemoglobin A1c

Question 20

oftebn caused by vit. 12 deficiency

Answer 20

megaloblastic anemia