Glia and the BBB

Question 1

3 major barriers between CNS and alk other tissues

Answer 1

BBB - huge potential surface area for contact between blood and CSF
Choroid plexus of lateral ventricles - CSF produces here, epithelial choroid plexus cells have tigh junctions
Subdural space - tight junctions prevent leakage

Note the superior sagital sinus is a site of major venous drainage, CSF and blood potentialy could meet here

Question 2

Barin capillaries

Answer 2

Lined with pericytes and astocyte endfeet.
Pericytes necessary for tight junctions and basement membrane formation.
Pericytes - encapsulate capillaries, could be linked to CO2 detection.

Question 3

Movement across the BBB

Answer 3

Transcellular lipophillic pathway
Active efflux carrier
Transport proteins
Receptor mediated transcytosis
Absorptive mediated transcytosis

Question 4

Glial and neuroglial cells

Answer 4

Non-neuronal cells whose function is to support neuronal cells both mechanically, physically and ionically around synapses. Insulate axons.
PNS -schwann cells, satellite cells
CNS - astrocytes, oligodendrocytes, microglial