GITRACT -after h-pylori infection

Question 1

what is endoscopy

Answer 1

it is invasive a tube with camera is lowered down git tract to look out for h-pylori and any malignancies, biopsies need to performed to confirm biopsies

Question 2

What are antacids , ADR and interactions

Answer 2

they neutralise acid and can be used in heartburn, dyspepsia and indigestion eg. calcium carbonate

Question 3

difference between alginates and antacids

Answer 3

alginates form a polysacharide gel on top of stomach contents like a raft where as antacids neutralises acid where the salt component binds with the hydrogen.

Question 4

H2 antagonists, MOA
ADR AND INTERACTIONS

Answer 4

inhibits acid secretion DG: Famotidine and nizatidine
MOA: competitive inhibitors of the h2 receptors on the parietal cells, inhibits activation of proton pump

Question 5

PPI not considered first line but can be used to eradicate h-pylori superior to h2

Answer 5

esomeprazole, pantoprazole and rabeprazole , irreversible inhibitor of proton pump. They are all Prodrugs and are activated in presence of acid . they are enteric coated

Question 6

PPI moa

Question 7

adverse effects of ppi

Answer 7

increase in ph for long term can lead to clostridium diffficile in stimach and aspiration of stomach contents into lungs can lead to pneumoniae

Question 8

promoting mucosal defence

Answer 8

misoprostol is pge1 analogue and binds to PGR receptor as pge2 and stimulates bicarbonate and mucous secretion contraindicated in pregnancy

Question 9

Coating agents

Answer 9

sucralfate and bismuth , buffer gastric acid

Question 10

h, pylori infection treatment

Answer 10

amoxicilin
- inhibits cell wall synthesis
clarithromysin
- inhibits protein synthesis and
esomeprazole
inhibits acids secretion

Alternative metronidazole, levofloxacin, and try ura breath 2 days after