GIT George H2 Antagonists

Question 1

MOA of H2 antagonists

Answer 1

-They inhibit gastric acid secretion by blocking the effect of histamine at the histamine H2-receptors in the parietal cells of the stomach

Question 2

examples of H2 antogonists

Answer 2

Cimetidine (Tagamet),
Ranitidine (Zantac),
Nazitidine (antizid)

Question 3

Cimetidine drug interactions - MOA

Answer 3

inhibit metabolism

Question 4

CImetidine drug interactions - drugs

Answer 4

Diazepam, Warfarin, Theophilline, Phenytoin

Question 5

Cimetidine possible side effects

Answer 5

Male lower spermcount, loss of libido, impotence, gynaecomastia

Question 6

Ranitidine, Nazitidine s/effects, d/i comparison to Cimetidine

Answer 6

-They do not have an effect on male sexual function & sperm
count
-Do not cause gynaecomastia
-Unlike cimetidine, have little or no potential for drug
interaction

Question 7

Proton Pump inhibitors MOA and examples

Answer 7

-They reduce gastric acid secretion by blocking the absorption of
hydrogen ions (protons) into the parietal cell by inhibiting H+/K+-
ATPase enzyme system (proton pump)

Question 8

Omeprazole indications

Answer 8

Uses: Zollinger-Ellison syndrome: rare, gastric producing tumor (Drug of choice)

              - Peptic ulcer
              - Reflux oesophagitis
              - Treatment & prevention of NSAID-induced erosion
              - Combined with certain antibiotics to eradicate Helicobacter

Question 9

Omeprazole possible side effects

Answer 9

Adverse Effects: Headache, Diarrhoea, Rashes, Dizziness

                               - Nausea, Vomiting, Pruritus, Alopecia
                               - Gynaecomastia, Blood disorders, Constipation

Question 10

Omeprazole Drug interactions

Answer 10

• Diazepam Omeprazole inhibits the metabolism
  - Warfarin & enhances the effects of these
  - Phenytoin etc drugs

Question 11

Lansoprazole difference to Omeprazole in indication

Answer 11

Not for Zollinger-Ellison syndrome