GIT George: antispasmodics

Question 1

antispasmodics MOA

Answer 1

competitively block acetylcholine at the GIT muscarinic receptors

Question 2

adverse effects of antispasmodics

Answer 2

Dry mouth, Blurred vision, Constipation

Urine retention, Muscular weakness

Question 3

contraindications of antispasmodics

Answer 3

Close angle glaucoma

Myasthenia gravis

Question 4

Name of drug that starts with a “B” and indication

Answer 4

“Buscopan” = Hyoscine Butyl Bromide

PS: Hyo scine…Bull Shit
Spasm GIT
GallStones (block bile duct; gallbladder attack; renal and biliary colic)

Question 5

Name of drug that starts with a “M” and indication

Answer 5

Mebeverine (“Colofac”)

Irritable colon
useful in patients with glaucoma or prostate hypertrophy

Question 6

Name of drug that starts with “P” and indication

Answer 6

Pirenzipine (M1 antagonist)

Peptic ulcer

Question 7

Drug used for Spasm GIT and also infant colic

Answer 7

DICYCLOMINE HYDROCHLORIDE (CLOMIN)
Also known as DICYCLOVERINE

DICYCLOMINE/SIMETHICONE

• Treatment of flatulence &abdominal discomfort due to entrapped gas
• Relieves infant colic

Question 8

two more bromide drugs

Answer 8

ATROPINE METHYLBROMIDE
-Treatment of peptic ulcer

PROPANTHELINE BROMIDE (PRO-BANTHINE)