Brainscape's Knowledge GenomeTM

Browse over 1 million classes created by top students, professors, publishers, and experts.


See full index

pharma > GIT drugs > Flashcards

GIT drugs Flashcards

1
Q

Cimetidine

A
  • H2 antagonist. (-tidine suffix)
  • Causes decreased gastric acid secretion in parietal cells.
  • Used in heart burn, peptic ulcers…
  • Can cause gynecomastia in men and inhibits CYTP450 so can be dangerous.
  • Other H2 antagonists - Ranitidine, Femotidine, and Nizatidine.
How well did you know this?
1
Not at all
2
3
4
5
Perfectly
2
Q

Ondansetron

A
  • Antiemetic drug, inhibits 5HT-3 receptor.

- Treats vomiting, can cause constipation and headache,

How well did you know this?
1
Not at all
2
3
4
5
Perfectly
3
Q

Scopalamine

A
  • Antiemetic drug, muscarinic antagonist.

- Used to treat motion sickness.

How well did you know this?
1
Not at all
2
3
4
5
Perfectly
4
Q

Metoclopramid

A
  • Antiemetic drug, D2 antagonist.
  • Treats vomiting, and has some upper GI prokinetic effects.
  • Can increase prolactin levels.
How well did you know this?
1
Not at all
2
3
4
5
Perfectly
5
Q

Aprepitant

A
  • Antiemetic drug, NK1 antagonist.
  • Treats vomiting.
  • Doesn’t have effects on dopamine, serotonin or muscarinic receptors so has less adverse side effects.
How well did you know this?
1
Not at all
2
3
4
5
Perfectly
6
Q

Sodium Bicarbonate

A
  • A systemic antiacid, weak base that is highly soluble and is rapidly absorbed. It reacts and neutralizes gastric acid.
How well did you know this?
1
Not at all
2
3
4
5
Perfectly
7
Q

Aluminium Hydroxide

A
  • A non-systemic antiacid, not so soluble and acts only locally in GIT.
  • Can lead to constipation!
How well did you know this?
1
Not at all
2
3
4
5
Perfectly
8
Q

Magnesium Hydroxide

A
  • A non-systemic antiacid, not so soluble and acts only locally in GIT.
  • Can lead to diarrhea!
How well did you know this?
1
Not at all
2
3
4
5
Perfectly
9
Q

Misoprostol

A
  • A prostaglandin acting as a protective agent for the gastric mucosa.
How well did you know this?
1
Not at all
2
3
4
5
Perfectly
10
Q

Sucralfate

A
  • A mucosal protective agent, acting as a barrier.

- Requires acidic environment to work, so is not combined with antiacids.

How well did you know this?
1
Not at all
2
3
4
5
Perfectly
11
Q

Colloidal Bismuth

A
  • A mucosal protective agent, by coating the ulcer protecting it, as well as acting as a bactericidal agent against H. pylori.
  • It causes dark feces and black teeth.
How well did you know this?
1
Not at all
2
3
4
5
Perfectly
12
Q

Omeprazole + Iansoprazole + Pantoprazole

A
  • Are PPI - Proton pump inhibitors ( -prazole suffix)
  • They directly inhibit the proton pumps, and they require an acidic environment to be active.
  • They are the 1st line of defense against GERD and duodenal or gastric ulcers.
  • Omeprazole is contraindicated in pregnancy!
How well did you know this?
1
Not at all
2
3
4
5
Perfectly
13
Q

Bethanechol

A
  • M2 agonist

- Prokinetic agent

How well did you know this?
1
Not at all
2
3
4
5
Perfectly
14
Q

Neostigmine

A
  • AChE inhibitor

- Prokinetic agent

How well did you know this?
1
Not at all
2
3
4
5
Perfectly
15
Q

Cisaprid

A
  • Excitatory presynaptic 5HT-4 receptor agonist

- Prokinetic agent

How well did you know this?
1
Not at all
2
3
4
5
Perfectly
16
Q

Erythromycin

A
  • Excitatory motilin receptor activator

- Prokinetic agent

17
Q

Magnesium compounds (magnesium hydroxide/ citrate)

A
  • Osmotic laxative
18
Q

Lactulose

A
  • Osmotic laxative

- Can be also used for hepatic encephalopathy

19
Q

Polyetheleneglycol

A
  • Osmotic laxative
20
Q

Psyllium

A
  • Bulk forming laxative
21
Q

Carboxymethylcellulose

A
  • Bulk forming laxative
22
Q

Dextrose

A
  • Bulk forming laxative
23
Q

Plant Gum

A
  • Bulk forming laxative
24
Q

Decusate Salts

A
  • Stool softeners
25
Q

Liquid Petroleum

A
  • Lubricant laxative
26
Q

Senna

A
  • Stimulant laxative
27
Q

Caster oil

A
  • Stimulant laxative
28
Q

Cascara

A
  • Stimulant laxative
29
Q

Bisacodyl

A
  • Stimulant laxative
30
Q

Phenolphthalein

A
  • Stimulant laxative
31
Q

Opioids used as antidiarrheals

A

Loperamide + Diphenoxylate + Opium Tincture

- Decrease bowel motility - feces goes back and forth not allowing it to be excreted.

32
Q

Octreotide

A
  • A somatostatin analog - Antidiarrheal drug.
  • Decreases acid production and decreases intestinal fluid…
  • Used to treat symptoms of VIPoma/ carcinoid syndrome/ gastrinoma…
33
Q

Anticholinergics used as antidiarrheals

A

Atropine + Belladonna Alkaloids + Hyoscyamine

- They decrease intestinal muscle tone and peristalsis, so slows down movement of feces.

34
Q

Bismuth Subsalucylate + Kaolin pectin + Activated Charcoal

A
  • These are absorbant antidiarrheal drugs.

- They coat the walls of GIT and bind to the causative agent which is then eliminated.

pharma (4 decks)

Brainscape helps you reach your goals faster, through stronger study habits.
© 2024 Bold Learning Solutions. Terms and Conditions