GiM Flashcards
1
Q
When does a de novo mutation occur?
A
In gametogenesis or in the fertilized egg itself so the parents don’t have the mutation
2
Q
What type of inheritance pattern does duchenne muscular dystrophy have?
A
X-linked
3
Q
when in development does lyonisation occur?
A
in the zygote/blastocyst stage
4
Q
why may some females have mild symtpoms of an X-linked disease only usually seen in men?
A
due to a skewed distribution of inactivation, more of the healthy X’s inactivated than the mutated X’s overall
5
Q
Does DNA or RNA have on OH group attached to its second carbon of its sugar?
A
RNA, the OH group interacts with the phosphate group on the adjacent carbon which makes it less stable than DNA
6
Q
What direction is DNA written from the sense strand?
A
5’ to 3’
