g.i tract - prof peters Flashcards

1
Q

carries food and liquid from the mouth to the stomach propelled by ……….?

A

peristalis

How well did you know this?
1
Not at all
2
3
4
5
Perfectly
2
Q

the upper and lower part of the oesophagus are bounded by what?

A

upper and lower oesophageal sphincters

How well did you know this?
1
Not at all
2
3
4
5
Perfectly
3
Q

the oesophagus is lined by what cell type

A

stratified squamous epithelium

How well did you know this?
1
Not at all
2
3
4
5
Perfectly
4
Q

the oesophagus musculature contains, striated and smooth.

what regions of the oesophagus would you find these

A

striated - upper thrid

smooth - remainder

How well did you know this?
1
Not at all
2
3
4
5
Perfectly
5
Q

what nerve innervates the oesophagus

A

vagus nerve CNX

How well did you know this?
1
Not at all
2
3
4
5
Perfectly
6
Q

what triggers the closure of the upper oesophageal sphincter

A

once food has entered the oesophagus

primary peristaltic wave (vagus nerve)

swallowing centre (pons and medulla)

How well did you know this?
1
Not at all
2
3
4
5
Perfectly
7
Q

what is the enteric nervous system

A

its the nervous sytsem that governs the GI system

How well did you know this?
1
Not at all
2
3
4
5
Perfectly
8
Q

what do the circular fibres do behind bolus during peristalsis

A

contract to squeeze it down to stomach

How well did you know this?
1
Not at all
2
3
4
5
Perfectly
9
Q

what do longitudinal fibres infront of bolus do, during peristalsis

A

contract to shorten distance to travel

How well did you know this?
1
Not at all
2
3
4
5
Perfectly
10
Q

after swallowing how many seconds later does the lower oesophageal sphincter open

A

2-3 seconds

prevents reflux

How well did you know this?
1
Not at all
2
3
4
5
Perfectly
11
Q

when would a secondary peristaltic wave occur

A

when sticky food becomes lodged in the oesophagus

How well did you know this?
1
Not at all
2
3
4
5
Perfectly
12
Q

what digest protein in the stomach

A

pepsin and HCl

How well did you know this?
1
Not at all
2
3
4
5
Perfectly
13
Q

approximatley how much gastric juices is produced by the gastric glands

A

2 litre/day

How well did you know this?
1
Not at all
2
3
4
5
Perfectly
14
Q

mechanical activity occurs as two types. what are they

A

orad stomach

caudad stomach

How well did you know this?
1
Not at all
2
3
4
5
Perfectly
15
Q

for storage of ingested material in the stomach. must stomach relax or contract

A

relax via vagus nerve

How well did you know this?
1
Not at all
2
3
4
5
Perfectly
16
Q

would you expect to find greater wave activity in the orad or the caudad region

A

caudad region

17
Q

where would you find thick musculature in the stomach

orad region or caudad region

A

caudad region

18
Q

why is there minimal mixing of contents for long periods in the orad region

A

allows for carbohydrate partial digestion by salivary glands

19
Q

what occurs during retropulsion

A

mixing of gastric contents, whilst reducing chyme to small particles, so that it passes through the pylorus

20
Q

Strength of antral wave determines escape of chyme through pyloric sphincter

which is goverened by what

A

gastric factors

duodenal factors

21
Q

what are the gastric factors that affect emptying of chyme

A

stretch of smooth muscle

stimulation of intrinsic nerve plexuses

increased vagus nerve activity and gastrin release

consistency of chyme

22
Q

what stimuli in the duodenum affects gastric emptying

A

fat - duodenum needs to prepare

acid - pancrease needs to prepare

hypertoncity - osmotically active

distension

23
Q

what is the gastric mucosa composed of

A

lining of stomach

pits, invaginations of the surface

glands, at the base of the pits

24
Q

in which region of the stomach would you find an increase in parietal and chief cells.

oxyntic or plyoric

A

oxyntic area

25
Q

which regions would you find d cells

pyloric or oxyntic

A

pyloric

26
Q

functions of gastric secretions

HCl

A

activates pepsiongen to pepsin

denatures protein

kills most microorganisms

27
Q

functions of gastric secretions

pepsinogen

A

inactive precursor of the peptidase

28
Q

functions of gastric secretions

histamine

A

stimulates HCl secretion

29
Q

functions of gastric secretions

Mucus

A

protective

(pyloric gland area and antrum)

30
Q

functions of gastric secretions

gastrin

A

stimulates HCl secretion

31
Q

functions of gastric secretions

somatostatin

A

inhibits HCl secretion

32
Q

what are the three phases of gastric acid secretion

A

cephalic phase - in the head

gastric phase - when food is in stomach

intestinal phase - after food has left stomach

33
Q

what are the three inhibition stages of gastric acid secretion

A

cephalic phase - vagal nerve activity decreases

gastric phase - ph falls as food exits stomach

intestinal phase - factors that reduce gastric motility, reduce gastric secretion

34
Q

Drugs that reduce gastric acid secretion are used in the treatment of…

A

peptic ulcer

gastro-oesophageal reflux disease

acid hypersecretion

35
Q

what drug acts as a proton pump inhibitor

A

omeprazole

36
Q

what conditions need to be met for the success of omeprazole

A

timing of dosing

orally once daily

full effect achieved after repeated dosing

37
Q
A