Gi Pharmacology Flashcards
Give an example of a H2 receptor antagonist and the usage
Ranitidine,
gord, peptic ulceration
What is the MOA of h2 receptor antagonists?
Block the H2 receptors on the parietal cells so they don’t respond to the histamine released by ECL cells. This reduces acid production.
What are the side effects of h2 receptor antagonists
Rare, but can include:
Diarrhoea, dizziness, headache, rash, tiredness
Who should not use H2 receptor antagonists and why
Not recommended for people with renal impairment, or breastfeeding mothers.
What are the DDIs of H2 receptor antagonists
React with the ‘nib’ class
PPIs - can interfere with the effectiveness of PPIs (Dec. metabolism of Omeprazole)
Describe the administration of H2 receptor antagonists
Tablet
Twice a day (short half-life)
What are some examples of PPIs
Omeprazole, Lansoprazole, Esomeprazole
What are PPIs used for
GORD, peptic ulceration, acid blockade in H.pylori treatment
What is the moa of ppis
Irreversibly bind to the active proton pumps of the parietal cells. This reduces acid production.
Delayed effect - proton pumps only active after eating, and not all are active at the same time.
What are the side effects of ppis
Headache, diarrhoea, constipation, abdominal pain, flatulence, fever, vomiting, nausea, rash
What are the adrs of ppis?
Increased Gastrin - More likely to get gastrin secreting tumour?
Qhat are the ddis of ppis?
Digoxin - increases the absorption.
Describe the administrtion of ppis?
Tablet
Max efficacy - after 2-3 days
What are some examples of antacids
Gaviscon (compound alginate), Aluminium Hydroxide, Bicarbonate
What are antacids used for
GORD, gastritis, indigestion
