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Gastroenterology yr 2 > GI pharmacology > Flashcards

GI pharmacology Flashcards

1
Q

to treat GERD, non-ulcer dyspepsia

A

Antacid - calcium carbonate, MgOH, AlOH

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2
Q

GERD, dyspepsia, not in a bleed

A

H2 receptor antagonist -

REVERSIBLE

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3
Q

GERD, PUD, acute GI bleed, Zollinger-ellison

A
  • PPI

IRREVERSIBLE inhibition

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4
Q

2 main differences between H2rAntago and PPI

A
  • PPI no renal excretion

- PPI decreases basal and meal acid secretion

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5
Q

To prevent NSAID-induced injury give

A

Prostaglandins - misoprostil

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6
Q

anti-diarrhea agents include

A

opioid agonists
bismuth
cholestyramine
octreotide slows transit

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7
Q

prokinetic/antispasmodic

A

5HT4 agonists - prucalapride-

Dopamine receptor antagonist

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8
Q

how do 5HT4 agonists work

A
  • increase transit
  • increase water content in stool
  • increase gastric emptying
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9
Q

Histamine receptor antagonists are

A

IRREVERSIBLE

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10
Q

H2R antagonists are often added to?

A

PPI - FOR NIght GERD

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11
Q

Antibmicrobials against H pylori infection can be combined with

A

PPIs

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12
Q

example of osmotic diarrhea

A

use of a PEG solution, lactulose

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13
Q

secretory diarrhea 2 examples

A

1) zollinger ellison

2) cholera toxin

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14
Q

example of steatorrhea type diarrhea -

A

cystic fibrosis - pancreatic insufficiency
celiac -
crohn’s -

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15
Q

2 examples of rapid transit

A

1) hyperthyroidism

2) diabetes

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16
Q

Antidiarrheal agents include

A

opioid agonists

17
Q

MOA of octreotide

A

inhibits gut hormones that promote motility - anti-diarrheal
- slows GI transit, increased absorption

18
Q

Location of 5HT3 receptors c/w 5HT4

A

proximal gut vs

small bowel/colon

19
Q

which neurotransmitter is important for inducing peristalsis

A

acetylcholine

20
Q

what is used in the proximal gut as a prokinetic agent

A

dopamine 2 receptor antagonist

21
Q

How does domperidone act

A

increases LES pressure
increases gastric emptying
anti emetic

22
Q

what can you use to treat IBS

A
  • SSRIs

TCA

23
Q

examples of antiemetics

A

5HT3 antagonists

Dopamine antagonists

Gastroenterology yr 2 (10 decks)

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