GI/Nutritional 50% Flashcards
(PPP 158)
MC pathogenic offender causing acute cholecystitis
E. coli
(PPP 158)
name three clinical manifestations of acute cholecystitis
CONTINUOUS pain - RUQ or epigastric
pain may be precipitated by fatty foods or large meals
nausea may be associated
may also show nausea, guarding, anorexia
(PPP 158)
four primary findings on PE for acute cholecystitis
FEVER (low-grade)
GALLBLADDER is PALPABLE, ENLARGED
+ Murphy’s sign
+ Boas sign
(PPP 158)
what is Murphy’s sign?
RUQ pain or inspiratory arrest with palpation of the gallblader
(PPP 158)
what is Boas sign?
what causes it?
referred pain to R shoulder or subscapular area
phrenic nerve irritation
(PPP 158)
you suspect acute cholecystitis - what is the initial diagnostic imaging test of choice?
ULTRASOUND = “initial test of choice”
(PPP 158)
what are you looking for with u/s in suspected acute cholcystitis?
thickened or distended gallbladder
pericholecystic fluid
sonographic Murphy’s sign
(PPP 158)
when do we order CT scan for acute cholecystitis?
mmm…it’s an alternative….not sure when we order it…
“CT scan: alternative to ultrasound & can detect complications”
(PPP 158)
what lab changes might be seen for diagnosing acute cholecystitis?
CBC with diff: INCREASED WBC (leukocytosis with left shift)
increased bilirubin
increased alk phos
increased LFTs
(PPP 158)
what is the most accurate test for acute cholecystitis?
HIDA SCAN!!
most accurate test
“cholecystitis is present if there is no visualization of the gallbladder”
(PPP 158)
mainstays of management of acute cholecystitis
NPO
IVF
ABX
cholecystectomy w/in 72 hrs (laproscopic is preferred)
(PPP 158)
what abx may be used for acute cholecystitis?
ceftriaxone + metronidazole
(PPP 158)
what do you do for acute cholecystitis if pt is nonoperative?
cholecystostomy (percutaneous drainage of the gallbladder)
(PPP 159)
what is chronic cholecystitis?
what is associated with it?
fibrosis and thickening of the gallbladder due to chronic inflammatory cell infiltration of the gallbladder evident on histopathology
almost always associated with gallstones
(PPP 165)
MC site for anorectal abscess
posterior rectal wall
(PPP 165)
what is MC pathogen causing anorectal abscess?
Staphylococcus aureus
(PPP 165)
what usually causes anorectal abscess?
“often results from bacterial infection of anal ducts or glands”
(PPP 165)
what is the primary management intervention for anorectal abscess & fistulas?
I&D
followed by
WASH = Warm-water cleansing Analgesics Sitz baths High-fiber diet
(PPP 165)
define anal fissure
“painful linear tear/crack in the distal anal canal”
(PPP 165)
define FISTULA
open tract b/w two epithelium-lined areas, seen esp w/ deeper abscesses
(PPP 165)
what are the PE findings of anal fissures?
LONGITUDINAL TEAR in the anoderm that usually extends no more proximally than the dentate iine
MC at posterior midline
(99% men, 90% women)
(PPP 165)
what is a common PE finding in chronic anal fissure patients?
skin tags
(PPP 165)
what are first line management measures for anal fissures?
warm water Sitz baths analgesics high fiber diet increased water intake stool softeners laxatives mineral oil
(PPP 165)
what is second line treatment for anal fissures?
TOPICAL VASODILATORS:
- nitroglycerin
- nifedipine ointment
(PPP 165)
what treatment option may reduce spasm of internal sphincter for anal fissures?
Botox injections (may be more effective than topical dilators)
(PPP 165)
when is surgery considered for anal fissures? what procedure?
refractory cases
consider lateral internal sphincterotomy
(PPP 165)
two primary facts about management of anal fissures
> 80% RESOLVE SPONTANEOUSLY
SUPPORTIVE MEASURES ARE FIRST LINE MANAGEMENT
(PPP 165)
clinical manifestations of anal fissures
severe painful rectal pain and bowel movements
causing the pt to
refrain from defecating,
bright red blood per rectum
(MDWise)
what is a common electrolyte problem that leads to an ileus or impaired bowel motility?
hypOkalemia
(MDWise)
MC mechanical etiologies for small bowel obstructions (4)
adhesions
incarcerated hernias
IBD/Crohn’s
CA/tumor
(MDWise)
MC mechanical etiologies for large bowel obstructions (3)
volvulus
diverticulitis/ischemic strictures
colorectal CA
(MDWise)
MC functional etiology for large bowel obstruction
Ogilvie’s Syndrome (colonic ileus)
(PPP 224)
describe disease process of acute pancreatitis
acinar cell injury –> INTRACELLULAR ACTIVATION OF PANCREATIC ENZYMES –> AUTODIGESTION OF PANCREAS
(PPP 224)
two MC causes of acute pancreatitis - and which is THE MC?
gallstones & alcohol abuse
gallstone MC (40%)
(ETOH 35%)
(PPP 224)
four drugs that can cause/contribute to acute pancreatitis
thiazides
protease inhibitors
exenatide
valproic acid
(also estrogens and didanosine)
(PPP 224)
clinical manifestations of acute pancreatitis
EPIGASTRIC PAIN: constant, boring pain often RADIATES TO THE BACK
- pain is worse if pt is supine or eating - pain RELIEVED BY LEANING FORWARD
N/V
FEVER
(PPP 224)
Two common PE exam findings with acute pancreatitis
EPIGASTRIC TENDERNESS
tachycardia
(PPP 224)
two extreme signs of acute pancreatitis only seen if the case is necrotizing or hemorrhagic
Cullen’s sign (periumbilical ecchymosis)
Grey Turner sign (flank ecchymosis)
(PPP 224)
diagnosing acute pancreatitis requires 2 of the three diagnostic criteria - name them
1 - acute onset of PERSISTENT SEVERE EPIGASTRIC PAIN often radiating to back
2 - lipase or amylase 3x ULN
3 - acute pancreatitis findings on imaging (CT, MRI, US)
aka
1 - RUQ/epigastric pain
2 - lipase 3x ULN
3 - imaging
(Jerrica’s Cards)
What are the diagnostic criteria for acute pancreatitis?
2/3 must be present:
- Epigastric pain
- Lipase 3x UNL
- Imaging w/ evidence
(Jerrica’s cards)
What imaging modality is best for diagnosing acute pancreatitis?
CT with contrast is best
US can be done
(Jerrica’s Cards)
Epigastric pain with significantly elevated lipase and ALT (3x UNL) is indicative of what condition?
Gallstone pancreatitis
(PPP 224)
four lab findings indicative of acute pancreatitis
amylase/lipase ALT hypocalcemia leukocytosis - - (also elevated glucose, bilirubin, triglycerides)
(PPP 224)
what are best initial tests for acute pancreatitis?
amylase/lipase
lipase is more specific than amylase
(PPP 224)
Why do we see hypocalcemia with acute pancreatitis?
necrotic fat binds to calcium lowering serum calcium levels (saponification)
(PPP 224)
when is transabdominal U/S recommended in suspected acute pancreatitis?
assess for gallstones and bile duct dilation
(PPP 224)
what is a ‘SENTINEL LOOP’ found on abdominal radiograph of suspected pancreatitis?
LOCALIZED ILEUS of a segment of small bowel in the LUQ
(PPP 224)
What is a COLON CUTOFF SIGN on abdominal radiograph of suspected acute pancreatitis?
abrupt collapse of colon near pancreas
pancreatic calcification is suggestive of chronic pancreatitis
(PPP 224)
when might we use MRCP for suspected acute pancreatitis?
to detect stones, stricture or tumor
(PPP 224)
what is the primary goal of management of acute pancreatitis?
REST THE PANCREAS
90% recover w/o complications in 3-7 days, require supportive measures only
(PPP 224)
what are the supportive measures of managing acute pancreatitis?
NPO
IVF - high-volume resuscitation (LR preferred)
ANALGESIA (meperidine (Demerol))
no abx
(PPP 224)
what is the thought process when considering abx for acute pancreatitis?
abx are not routinely used
IF severe infected pancreatic necrosis is seen (eg >30% necrosis on CT or MRI), then broad spectrum abx (imipenem) may be used
(PPP 225)
What is Ranson’s Criteria?
a way to determine prognosis of acute pancreatitis
(PPP 225)
five factors of Ranson’s Criteria for admission for acute pancreatitis
glucose (>200 mg/dL) age (>55 yrs) LDH (>350 IU/L) AST (>250 IU/dL) WBC (>16,000/microL)
(PPP 224)
how do we score or interpret Ranson’s Criteria?
> or = 3: severe pancreatitis likely
<3: severe pancreatitis unlikely
(PPP 225)
what is the MC etiology for CHRONIC pancreatitis?
ETOH abuse (70%)
sometimes it is idiopathic
(PPP 225)
what is the hallmark triad of clinical manifestations of CHRONIC pancreatitis?
1 - calcifications
2 - steatorrhea
3 - DM
(only seen in 1/3 of pts though)
(PPP 225)
what are common findings for amylase/lipase in CHRONIC pancreatitis?
amylase & lipase usually normal (or only mildly elevated)
(PPP 225)
common CT findings in CHRONIC pancreatis?
calcification of pancreas
(PPP 225)
what are common findings on abdominal radiographs for CHRONIC pancreatitis?
calcified pancreas
(PPP 225)
pancreatic function testing - what’s it for? what do we usually get from it?
FECAL ELASTASE is most sensitive and specific to chronic pancreatitis
pancreatic stimulation with secretin & CCK (not usually done)
(PPP 225)
mainstays of management of chronic pancreatitis
ETOH abstinence pain control low fat diet vitamin supplementation oral pancreatic enzyme replacement
pancreatectomy only if rectractable pain despite med therapy
(SmartyPance)
list 4 common BILIARY causes of RUQ abdominal pain
biliary colic
acute cholecystitis
acute cholangitis
sphincter of Oddi dysfunction
(SmartyPance)
list 4 HEPATIC reasons for RUQ abdominal pain
acute hepatitis perihepatitis (Fitz-Hugh-Curtis syndrome) liver abscess Budd-Chiari syndrome portal vein thrombosis
(SmartyPance)
list four common causes of LUQ abdominal pain
splenomegaly
splenic infarct
splenic abscess
splenic rupture
(SmartyPance)
list 8 common causes of EPIGASTRIC abdominal pain
acute MI acute pancreatitis chronic pancreatitis peptic ulcer disease GERD gastritis functional dyspepsia gastroparesis
(SmartyPance)
list 7 common causes of lower abdominal pain
appendicitis diverticulitis nephrolithiasis pyelonephritis acute urinary retention cystitis infectious colitis
(SmartyPance)
Pt presents with anorexia - what are some common items on the differential?
appendicitis gastric ulcers duodenal ulcers gastric cancer lower GI bleed carcinoma of gallbladder pancreatic carcinoma
(PPP 233)
two MC etiologies for appendicitis
fecalith
lymphoid hyperplasia
(PPP 233)
anorexia
periumbilical or epigastric pain followed by RLQ abdominal pain (12-18 hrs later)
n/v, vomiting occurring after pain
appendicitis clinical manifestations
(PPP 233)
Rovsing sign, and what diagnosis it’s associated with -
RLQ pain with LLQ palpation
appendicitis
(PPP 233)
obturator sign and associated diagnosis
RLQ pain with internal & external hip rotation with flexed knee
appendicitis
(PPP 233)
what is psoas sign and what associated diagnosis?
RLQ pain with right hip flexion/extension (raise leg against resistance)
appendicitis
(PPP 233)
what is McBurney’s point tenderness and associated diagnosis
point 1/3 the distance from the anterior superior iliac spine & navel
appendicitis
(PPP 233)
what is preferred imaging of choice in adults with suspected appendicitis
CT scan
(PPP 233)
management of appendicitis
appendectomy, laparoscopic preferred when possible
(PPP 229)
post-surgical adhesions are the most common etiology for…..
small bowel obstruction
60% are caused by adhesions
(PPP 229)
what is the one MC cause of large bowel obstruction?
malignancy
(PPP 229)
SBO acronym CAVO =
Crampy abd pain
Abd distention
Vomiting
Obstipation (no flatus)
= four hallmark symptoms of small bowel obstruction (these are usually late findings)
(PPP 229)
what bowels sounds are usually found upon PE for bowel obstruction?
high-pitched tinkles on auscultation and visible peristalsis (early obstruction)
(PPP 229)
what signs on abd xray indicate bowel obstruction?
multiple air-fluid levels in a STEP-LADDER appearance,
dilated bowel loops
(PPP 229)
Abd XRay showing multiple air-fluid levels in a STEP-LADDER appearance and dilated bowel loops
think bowel obstruction
(PPP 229)
CT scan showing a transition zone from dilated loops of bowel with contrast to an area of bowel with no contrast….think:
bowel obstruction
(PPP 229)
what do you do to manage NONSTRANGULATED bowel obstruction?
NPO (bowel rest)
IVF
bowel decompression (NG suction if severe vomiting
(PPP 229)
what do you do to manage strangulated bowel obstruction?
surgery
(PPP 228) BUZZWORDS
BENT INNER TUBE or COFFEE BEAN SIGN on xray
think VOLVULUS
(PPP 228)
What is a volvulus?
twisting of any part of the bowel at its mesenteric attachment site
(PPP 228)
What is the MC site for volvulus in older adults?
sigmoid colon and cecum
(PPP 228)
what is the MC site for volvulus in children?
midgut and ileum
(PPP 228)
what are clinical manifestations of obstruction caused by volvulus?
crampy abd pain distention n/v constipation TYMPANIC ABD with tenderness to palpation
(PPP 228) BUZZWORDS
BIRD-BEAK appearance on abd CT
volvulus
(PPP 228)
first step in management of volvulus
endoscopic decompression (proctosigmoidoscopy) is initial treatment of choice
often rectal tube is left in place to decrease acute recurrent and decrease distention
(PPP 228)
what usually follows decompression in the management of volvulus?
elective surgery
due to the high rate of recurrence
(PPP 228)
when is immediate surgical correction required when considering a patient’s volvulus?
if pt has
- peritonitis
- gangrene
- endoscopic decompression is unsuccessful
(PPP 228)
two surgical options for correcting volvulus
primary anastomosis
Hartmann’s procedure
(SmartyPance)
NIH BMI-related guidelines for bariatric surgery
BMI >40 (basically 100 pounds above ideal body wt)
BMI >35 with a medical problem related to morbid obesity
(SmartyPance)
three non-BMI related NIH guidelines for bariatric surgery
- must have failed other non-surgical wt loss programs
- must be psychologically stable
- must be able to follow post-op instructions
- obesity is not caused by a medical disease such as endocrine disorder
(SmartyPance)
three types of RESTRICTIVE types of bariatric surgery
adjustable gastric banding
vertical banded gastroplasty
sleeve gastrectomy
(SmartyPance)
what are two types of MALABSORPTIVE PROCEDURES of bariatric surgery
biliopancreatic diversion
biliopancreatic diversion with/without duodenal switch
(SmartyPance)
what is a type of a COMBINATION type of bariatric surgery (combination of restrictive and malabsorptive procedures)
Roux-en-Y Gastric Bypass
(SmartyPance)
what are the most common types of bariatric procedures used in the US?
Roux-en-Y (RNYGB)
Adjustable Gastric Banding (AGB)
Vertical Banded Gastroplasty (VBG)
Biliopancreatic Diversion with/without Duodenal Switch (BPD/DS)
(SmartyPance)
early complications of bariatric surgery
anastomotic leak DVT & PE bleeding infection splenic injury
(SmartyPance)
what are late complications for bariatric surgery?
malnutrition and nutritional problems marginal ulcer and anastomotic strictures internal hernia cholelithiasis band slippage band erosion esophageal dilatation
(SmartyPance)
Charcot’s triad
fever
jaundice
RUQ abd pain
(PPP 159)
what is ascending cholangitis?
biliary tract infection secondary to obstruction of the common bile duct (eg gallstones, malignancy)
(PPP 159)
MC gram negative pathogen causing cholangitis
E. coli is MC
2nd place goes to Klebsiella, then Enterobacter, B. fragilis
(PPP 159)
Does Charcot’s triad apply to acute ascending cholangitis? what is it?
yes - common clinical manifestations of acute ascending cholangitis
Charcot’s Triad = fever chills + RUQ pain + jaundice