GI/Nutrition 2 Flashcards
complication of gallstones 2/2 to infected obstruction of the cbd
cholangitis
mcc of cholangitis
e. coli
charcot’s triad
ruq pain
jaundice
fever
reynold’s pentad
charcot’s triad
PLUS
hypotn
AMS
besides reynold’s pentad, 2 additional sx of cholangitis
light colored stool
tea colored urine
pruritis + jaundice =
primary sclerosing cholangitis
chronic liver dz involving inflammation/fibrosis of the intrahepatic and extrahepatic ducts
primary sclerosing cholangitis
what pt pop makes you think of primary sclerosing cholangitis
ulcerative colitis
cholangiography finding of PSC
fibrosis of bile ducts
imaging for cholangitis: initial vs gs
initial: US
gs: ERCP
indication to skip US and proceed directly to ERCP w. suspected cholangitis
charcot’s triad + abnl LFTs
management of cholangitis
empiric abx
ercp w. stent
post acute cholecystectomy
all causes of cholangitis (6)
cholelithiasis
post op choledocholithiasis stricture
neoplasm (ampullary carcinoma)
pancreatic pseudocyst/pancreatitis
ERCP/PTC
biliary stent
lab elevations associated w. cholangitis
elevated: WBC, bilirubin, ALP
positive blood cultures
what is supporative cholangitis
severe infxn w. sepsis
“pus under pressure”
tx for supporative cholangitis
IVF
abx
decompression: ERCP w. papillotomy vs PTC w. catheter drainage vs laparotomy w. T-tube
cystic collection of tissue, fluid, and necrotic debris surrounding the pancreas
pancreatic pseudocyst
2 conditions associated w. pancreatic pseudocyst
pancreatic (chronic > acute)
trauma to chest (ex steering wheel)
pancreatic pseudocysts generally occur how long after acute pancreatitis
2-3 weeks
characteristic appearance of pancreatic pseudocyst
fibrous capsuel w. no epithelial lining
PE finding of pancreatic pseudocyst
abdominal mass
indication for surgical intervention w. pseudocyst
if persists past 4-6 weeks:
percutaneous drainage vs pancreaticogastrostomy
complications of pancreatic pseudocyst (7)
infxn -> pertonitis
bleeding
fistula
pancreatic ascites
gastric outlet obstruction
SBO
biliary obstruction
mcc of pancreatic pseudocyst
chronic alcoholic pancreatitis
tumor marker associated w. liver ca
AFP
3 rf for hepatic carcinoma
hepatitis B and C
hemochromatosis
cirrhosis
benign liver lesions
cavernous hemagioma
hepatocellular adenoma
infantile hemangioendothelioma
imaging guidelines for liver lesions
< 1 cm: contrast MRI w. f/u US q 3 mo
guidelines for HCC screening
+/- pt’s w. cirrhosis and chronic hep B
screen w. periodic AFP and US
tx for HCC
-transplant: single tumors < 5 cm OR </= 3 cm limited to the liver
-resection - high rate of recurrence
epigastric pain that radiates to the back + wt loss, jaundice, pruritis
pancreatic ca
most clearly established rf for pancreatic ca
smoking
mc location for pancreatic ca
head of the pancreas
tx for pancreatic ca
pancreaticoduodenectomy (whipple)
tumor marker for pancreatic ca
CA-19-9
what is courvoisier’s sign
nontender, palpable gallbladder
mc type of pancreatic ca
ductal adenocarcinoma at the head of the pancreas
5 rf for pancreatic ca
cigs
etoh
pancreatitis
dm
obesity
what is virchow’s node
signal node in the left supraclavicular fossa
the pain of pancreatitis/pancreatic ca is relieved by
sitting and leaning forward
labs of pancreatic ca
-elevated: amylase, direct bilirubin, CEA, CA19-9
-glucose intolerance
what happens in a whipple procedure
removal of: antrum, part of duodenum, head of pancreas, gallbladder
results in:
-choledochojejunostomy: bile flow
-gastrojejunostomy: passage of food
-pancreaticojejunostomy: pancreatic juice flow
2 types of hiatal hernia
type 1: sliding -> mc
type 2: paraesophageal
describe hiatal hernia
both gastroesophageal junction AND portion of the stomach herniate into the thorax -> gastroesophageal junction is above the diaphragm
describe paraesophageal hiatal hernia
gastroesophageal junction remains below the diaphragm
which type of hiatal hernia is high risk for strangulation
paraesophageal
hiatal hernias are mc asymptomatic, but what are 3 possible sx
heartburn
chest pain
dysphagia
complications of sliding hiatal hernia
reflux esophagitis
barrett’s/esophageal ca
aspiration
3 complications of paraesophageal hiatal hernia
obstruction
hemorrhage
incarceration/strangulation
dx for hiatal hernia
barium upper GI studies
upper endo
tx for hiatal hernia - type 1 vs type 2
type 1: antacids, lifestyle, +/- nissen fundoplication
type 2: nissen fundoplication
what part of the GIT is usually spared w. crohn’s
rectum
if rectum is involved, think UC
pattern of involvement w. crohn’s vs UC
crohn’s: skip lesions
UC: continuous
which type of IBD involves bloody diarrhea
UC
which type of IBD involves severe abd pain
crohn’s
what type of IBD is associated w. perianal dz
crohn’s
which type of IBD involves fistulas
crohn’s
ulcers associated w. crohn’s vs UC
crohn’s: aphtoid/deep ulcers, cobblestoning
UC: erythematous/friable/superficial ulcers
what is this showing
deep ulcers -> crohn’s
what is this showing
cobblestoning -> crohn’s
4 radiographic findings of crohn’s
string sign
RLQ mass
fistula
abscesses
radiographic finding of UC
tubular lead pipe appearance
what is this showing
string sign of terminal ileum -> crohn’s
what is this showing
lead pipe apperance -> UC
histologic features of crohn’s vs UC
crohn’s: transmural, non caseating granulomas
UC: mucosa-only crypt abscesses
association of smoking: crohn’s vs UC
crohn’s: worsens
UC: protective
serology associated w. crohn’s vs UC
crohn’s: ASCA
UC: p-ANCA
common presentation of UC (4)
bloody pussy diarrhea
rectal/lower quadrant pain
fever
urgency
mc site for UC
rectum
lab findings of UC
elevated: WBC, ESR
anemia
2 complications of UC
toxic megacolon
colorectal ca
4 systemic sx of crohn’s
oral/aphtous ulcers
severe anemia
polyarthralgia
fatigue
mc site for crohn’s
terminal ileum
4 complication of crohn’s
strictures
obstruction
abscess
fistula
work up for IBD (3)
upper GI series
colonoscopy w. bx
serology
most valuable dx test for IBD
colonoscopy
consider _ over colonoscopy in UC to reduce risk of bowel perf
flex sigmoidoscopy
complication of UC
toxic megacolon
mainstay of pharm for IBD
5-aminosalicylic acid drugs (ex sulfasalazine)
t/f: UC is more common in smokers and ex smokers
t!
GIB, fulminant colitis, toxic megacolon
UC
fistulas and renal stones
crohn’s
mc type of small bowel carcinoma
adenocarcinoma in the duodenum
mc presenting sx of small bowel tumors
intermittent, crampy abdominal pain
4 rf for small bowel carcinoma
-hereditary nonpolyposis colorectal ca (HNPCC)
-cystic fibrosis
-crohn’s
-etoh, refined sugar, red meat, salt/smoked foods
dx for small bowel ca
CT
endoscopy
fobt
majority of small bowel cancers are positive for what tumor marker
CEA
tx for small bowel ca
surgical resection
chemo
first sign of jaundice
slceral icterus
jaundice is seen w. serum bilirubin > _
2.5
causes of jaundice (6)
hemolysis/ineffective erythropoiesis
liver dysfxn
biliary tract obstruction
physiologic of newborn
gilbert
dubin-johnson
pathway of Hgb breakdown
- Hgb is broken into: heme + globin
- globin: broken into aa
- heme: broken into iron and protoporphyrin
- iron: recycled
- protoporphyrin: convrted to unconjugated bilirubin (UCB)
what happens to UCB (unconjugated bilirubin)
- transported by albumin to the liver for conjugation by uridine glucoronyl transferase (UGT) -> creates conjugated bilirubin ->
- conjugated bilirubin is transferred to bile -> 3. bile is transferred to the gallbladder ->
- bile is converted to urobilinogen ->
- uriblinogen oxidized to stercobilin (stool) and uriobilin (urine)
labs to evaluate jaundice (4)
Tbili and unconjugated bili
ALP/ALT/AST
PT/INR
albumin
jaundice PLUS normal LFTs
rule out hepatic injury/biliary tract dz
jaundice plus predominant ALP elevation
biliary obstruction
vs
intrahepatic cholestasis
jaundice plus predominant AST/ALT elevation
intrinsic hepatocellular dz
jaundice PLUS elevated INR
obstructive jaundice
which type of bilirubin suggests hemolytic anemia
unconjugated
think of _ when you see elevated unconjugated bilirubin/hemolytic anemia (2)
drugs
gilbert syndrome
think _ when you see elevated conjugated bilirubin (4)
biliary obstruction
intrahepatic cholestasis
hepatocellular injury
genetic condition
post op jaundice should clear by week _
3
5 causes of PREhepatic post op jaundice
hemolysis (prosthetic valve)
resolving hematoma
transfusion rxn
post cardiopulmonary bpass
blood transufsion
causes of post op hepatic jaundice (lots!)
drugs
hypotn
hypoxia
sepsis
hepatitis
preexisting cirrhosis
right sided heart failure
hepatic abscess
gilbert
crigler-najjar
dubin johnson
TPN
causes of post op POSThepatic jaundice (lots!)
choledocholithiasis
stricture
cholangitis
cholecystitis
biliary duct injury
pancreatitis
sclerosing cholangitis
pancreatic ca
gallbladder ca
biliary stasis
ceftriaxone
labs suggesting hemolysis
elevated: LDH, reticulocytes, fragmented RBCs on smear
decreased: haptoglobin Hct
first manifestation of conjugated hyperbilirubinemia
tea colored urine
what is melena
black tarry stool
causes of melena (5)
upper GIB
peptic ulcer
esophageal ulcer
mallory weiss tear
variceal hemorrhage/portal HTN
malignancy
what is hematochezia
BRBPR
causes of hematochezia (4)
lower GIB
hemorrhoids
anal fissures
polyps
colorectal ca
painless bleeding w. wiping
hemorrhoids
severe rectal pain w. defecation
anal fissures
painless rectal bleeding
no red flag signs
polyps
type of anemia: acute GIB vs chronic GIB
acute: normocytic
chronic: microcytic
gs test for hematochezia
colonoscopy
gs test for melena
EGD
tx for hematochezia and melena (4)
-endoscopic thermal probe vs clips vs injection
-angiographic embolization
-endoscopic intravariceal cyanoacrylate injxn
-band ligation
4 cardinal signs of strangulated bowel
fever
tachy
leukocytosis
localized abd tenderness
5 causes of volvulus
birth defect causing malrotation - mc
constipation
hirschprung dz
pregnancy
abdominal adhesions
mc part of colon affected by volvulus
sigmoid colon
2nd is cecum
order of imaging when SBO is suspected
abdominal XR series
abdominopelvic CT w. contrast
XR finding of volvulus
coffee bean/kidney bean sign
aka bent inner tube sign
what is this showing
bird beak sign -> volvulus
management of volvulus
emergent surgery
mcc of SBO in kiddos and worldwide
hernias
don’t forget to r.o _ with SBO
incarcerated hernia
define incomplete vs complete bowel obstruction
incomplete: some gas in colon
complete: no gas in colon
initial management w. all SBO pt’s (4)
NPO
NGT
IVF
FC
what 2 tests can distinguish partial vs complete bowel obstruction
CT w. contrast
SBFT
ABCs of SBO
- adhesions
- bulge - hernia
- cancer
tx for complete SBO
laparotomy w. lysis of adhesions
how to remember all causes of SBO
give bad cramps:
gallstone illeus
intussusception
volvulus
external compression SMA syndrome
bezoars
abscess
diverticulitis
crohn’s
radiation
annular pancreas
meckel’s diverticulum
peritoneal adhesions
stricture
mc indication for abd surgery in crohn’s pt’s
SBO due to strictures
cause of SBO for pt on coumadin
bowel wall hematoma
indications to lower threshold for surgery w. SBO
increasing leukocytosis
fever
tachycardia/tachypnea
increasing abd pain
absolute indication for surgery w. partial SBO
peritoneal signs -> free air on AXR
_ commonly mimics SBO
paralytic ileus -> diffuse gas distension, including colon
dx for anal fissures
anoscopy
hallmark anoscopy finding of anal fissures
thickened mucosa -> sentinel pile below fissure
dx for anal abscess
DRE
+/- CT if recurrent
dx for perianal fistula
exam
proctoscope
tx for anal fissures (5)
- fluid/fiber
- stool softeners
- sitz baths
- nitroglycerin/CCB ointments
- botox
tx for anal abscess
surgical drainage
sitz baths
analgesics
stool softeners
high fiber diet
+/- abx if high risk
tx for anal fistula
fistulotomy
what type of anal fissure is commonly due to straining during constipation
posterior midline
treatment for anal fissure that does not respond to conservative management
lateral anal sphincterotomy
mc location for anal fissures
posterior midline
4 indications for abx post op for anal abscess
cellulitis
immunosuppression
DM
heart valve abnl
what pt pop do you think of w. anal fistula
crohn’s
what is goodsall’s rule
anterior anal fistulas: course straight and exit anteriorly
posterior anal fistulas: curved track
thick suture placed thru anal fistulae tract to allow slow transection of sphincter muscle
seton
chronic anal fissure triad
fissure
sentinel pile
hyertrophied anal papilla
consider what dz’s w. chronic anal fissure (4)
IBD
anal ca
STIs
AIDS
2 types of GI ulcer to know
gastric
duodenal
rf for increased incidence of duodenal/gastric ulcers AND decrease in rate of healing
cigs
mc type of ulcer
anterior/proximal duodenal
pain decreases w. food
duodenal ulcer
mcc of PUD
h pylori
2 complications of posterior duodenal ulcer
gastroduodenal a bleed
acute pancreatitis
rare cause of PUD
zollinger ellison
4 causes of gastric ulcers
h.pylori - mc
NSAIDs
GERD
cigs
common presentation of gastric ulcers
-gnawing/burning pain that radiates to the back
-worse w. food
mc location for gastric ulcers
lesser curvature of antrum
mcc of non-hemorrhagic GIB
PUD
what type of bleeding is associated w. PUD
melena
gs dx for PUD
upper endo w. bx
managment of PUD
PPI for all
abx if h pylori
confirm eradication of h pylori
abx options for h pylori
metro + omeprazole + clarithro
vs
clarithro + ampicillin + ppi
8 rf for PUD
male
smoking
ASA/NSAIDs
uremia
ZE syndrome
h pylori
trauma
burns
3 indications for surgery w. bleeding duodenal ulcer
intractable hemorrhage
obstruction
perforation
what operation is used for ulcer hemorrhage/obstruction/perf
distal gastrectomy w. excision
3 types of hemorrhoids
internal
external
strangulated
presentation of internal hemorrhoids
painless brbpr
+/- mucus d.c, sensation of incomplete evacuation
presentation of external hemorrhoids
pain
no bleeding
which type of hemorrhoid is higher risk for thrombosis
external
dx for hemorrhoids
anoscopy
+/- sigmoidoscopy vs colonoscopy
tx for internal hemorrhoids
-stool softeners sitz baths, topical analgesics, hamamelis (witch hazel compress)
-bleeding: injection sclerotherapy (5% phenol in vegetable oil)
-larger/prolapsed/refractory: rubber band ligation
indication for excision of hemorrhoid
thrombosed external
3 hemorrhoid quadrants
left lateral
right posterior
right anterior
degrees of hemorroids
first: does not prolapse
second: prolapses w. defacation, self reduces
third: prolapses w. defecation/valsalva, requires manual reduction
fourth: prolapsed, not reducible
4 complications of hemorrhoidectomy
exsanguination
infxn
incontinence
stricture
contraindication for hemorrhoidectomy
crohn’s
tx for protruding internal hemorrhoids
rubber band ligation
5 types of hernias to know
hiatal
ventral
incisional
umbilical
inguinal
which type of hernia is mc congenital
umbilical
indication for surgery w. umbilical hernia
persists past 2 yo
mc type of inguinal hernia
indirect
pathway of indirect hernia
thru internal inguinal ring -> down inguinal canal -> into scrotum
i = internal inguinal ring
pathway of direct inguinal hernia
thru external inguinal ring at hesselbach triangle
3 complications of hernias
obstruction
incarceration
strangulation
dx for hernia
exam
US
what type of inguinal hernia is felt on the side of the finger during exam
direct
what type of inguinal hernia is felt on the tip of the finger during exam
indirect
5 rf for ventral hernia
abd surgery
age
obesity
wound infxn
surgical drains
which type of inguinal hernia is congenital and generally happens before 1 yo
indirect
what type of hernia very rarely strangulates
ventral
what type of hernia has a high incidence of strangulation
femoral
toxic megacolon is mc a complication of
IBD: UC > crohn’s -> mc
pseudomembranous colitis
4 sx of toxic megacolon
fever
distended abd
pertonitis
shock
imaging for toxic megacolon
KUB showing dilated colon > 6 cm
dx for toxic megacolon
at least 3 of the following:
radiographic evidence
fever > 101.5
HR > 120
neutrophilic leukocytosis
anemia
what is this showing
toxic megacolon
tx for toxic megacolon
decompression
+/- colostomy vs complete resection
3 radiographic findings of toxic megacolon
dilated colon > 6 cm
loss of colonic haustrations
segmental colonic parietal thinning