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PPT > GI MC4 > Flashcards

GI MC4 Flashcards

1
Q

Anastrozole

A

aromatase inhibitor

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2
Q

vagina adverse effects of Anastrozole

A

vaginal dryness, vaginal bleeding,

hair thinning,

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3
Q

GI adverse effects of Anastrozole

A

anorexia, nausea, vomiting, diarrhoea,

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4
Q

bone adverse effects of Anastrozole

A

arthralgia, arthritis, bone fractures, bone pain,

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5
Q

skin adverse effects of Anastrozole

A

rash (including stevens-johnson syndrome), cutaneous vasculitis,

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6
Q

head adverse effects of Anastrozole

A

Hot flushes, asthenia and drowsiness -may affect driving or operate machinery,

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7
Q

other adverse effects of Anastrozole

A

Slight increase in total cholesterol

Very rarely allergic reactions including angioedema and anaphylaxis

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8
Q

Tamoxifen

A

oestrogen receptor antagonist

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9
Q

SSRIs affect on breast cancer treatment

A

can inhibit metabolism of tamoxifen

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10
Q

warfarin affect on breast cancer treatment

A

Tamoxifen inhibits CYP3A4 therefore increasing risk of bleeding

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11
Q

chemo regime

A

Induction
Consolidation
Maintenance

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12
Q

induction

A

intensive treatment aimed at destroying as many leukaemia cells as possible and achieving remission

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13
Q

induction duration

A

4-6 weeks

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14
Q

Consolidation

A

aimed at remission and preventing spread. Often involves intra-spinal injections and then tablets.

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15
Q

Maintenance

A

Involves regular tablets and possible injections.

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16
Q

Maintenance duration

A

lasts 2 years (girls) or 3 years (boys)

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17
Q

Hyper-CVAD chemo combination

A

Cyclophosphamide, vincristine, doxorubicin, dexamethasone

18
Q

why do we use combo chemo

A

exploits dif stages of cell cycle

19
Q

Cyclophosphamide

A

bifunctional alkylating drug

20
Q

Cyclophosphamide side effecs

A

Impaired fertility in future
Bone marrow suppression and neutropenia
Can develop other malignancies → e.g acute myeloid leukaemia, bladder cancer

21
Q

how to reduce rick of chemo bladder cancer

A

mesna

22
Q

mesna

A

mercaptoethane sulphonic acid prior to treatment

23
Q

Vincristine

A

Vinca alkaloids- mitotic inhibitors

24
Q

how does vincristine work

A

block mitosis in metaphase- tubulin molecules fail to polymerize in the presence of vinca alkaloids
in anaphase dissolution of the mitotic spindle leads to cell death

25
Q

Doxorubicin

A

Anthracycline - cytotoxic antibiotic

26
Q

Doxorubicin side effect

A

dilated cardiomyopathy .

27
Q

Methotrexate starts when

A

6 week chemotherapy induction

28
Q

Methotrexate

A

folic acid antagonist

29
Q

hwo is Methotrexate excreted

A

renally

30
Q

Methotrexate main side effect

A

hepatotoxicity

31
Q

why monitor FBC with methotrexate

A

monitor platelet count as can cause toxicity to bone marrow

32
Q

Chemotherapy GI side effects

A

diarrhoea, sore mouth, nausea and vomiting

33
Q

Chemotherapy Bone marrow side effects

A

myelosuppression can lead to anaemia, neutropenia and thrombocytopenia

34
Q

Chemotherapy hair side effects

A

partial/ total alopecia

35
Q

Chemotherapy fertiloity side effects

A

Reproduction: can affect both men and women

36
Q

Chemotherapy tumour lysis syndrome

A

rapid breakdown of malignant cells can cause hyperuricemia, hyperkalaemia, hypophosphatemia, hypocalcemia with consequent renal damage/ arrhythmias

37
Q

Capecitabine

A

base analogue anti-metabolite

38
Q

Capecitabine MOA

A

Interferes with DNA synthesis- stops cells making and repairing DNA
It is a pyrimidine antagonist and is a prodrug of flurouracil

39
Q

Oxaliplatin

A

platinum compound

40
Q

Cisplatin and carboplatin are used for

A

solid malignancy

41
Q

side effects of platinum compounds

A 
Severe nausea and vomiting
Nephrotoxicity with renal impairment (hydration important) 
Ototoxicity 
Peripheral neuropathy 
Myelosuppression

PPT (8 decks)

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