GI Infections

Question 1

Watery diarrhea pathogens

Answer 1

Vibro cholera, Enterotoxigenic E. coli, Enteropathogenic E. coli, rotavirus, norovirus

Question 2

Inflammatory diarrhea pathogens

Answer 2

Salmonella, Shigella, Campylobacter, Yersinia, Enterohemorrhagic E.coli, Enteroinvasive E. coli, Enteroaggretative E. coli, C diff

Question 3

treatment

Answer 3

1. Fluid Replacement
2. anti-diarrheals (Watery only)
3. Probiotics
4. Fecal transplant

Question 4

C diff initial infection mild or moderate clinical data

Answer 4

WBC < 1.5 * baseline

Question 5

C diff initial infection mild or moderate drug

Answer 5

metronidazole 500 mg PO q8h x 10-14 days

Question 6

C diff initial infection severe data

Answer 6

WBC >15,000

Scr > 1.5 x baseline

Question 7

C diff initial infection severe drug

Answer 7

vancomycin 125 mg PO Q6h x 10-14 days

Question 8

C diff initial infection severe and complicated data

Answer 8

hypotension, shock, ileus, toxic megacolon

Question 9

C diff initial infection severe and complicated drug

Answer 9

vancomycin 500 mg PO q6h + motronidazole 500 mg PO q8h, may add PR vanc for complete ileus

Question 10

C diff first relapse drug

Answer 10

treat with same agent as before, but if severe treat as severe

Question 11

C diff 2nd relapse drug

Answer 11

vancomycin (with taper and/or pulse dose)

Question 12

C diff alternate drugs

Answer 12

Rifamixin, Nitrazoxanide, IVIG, Fidaxomicin, Tigecycline, fecal transplant, surgery

Question 13

Travelers diarrhea treatment

Answer 13

1. ORS
2. antimotility agents
3. 500 mg of cipro BID or 400 mg norfloxacilin BID for 3-5 days

Question 14

Travelers diarrhea alternate drugs

Answer 14

azithromicin, rifamixin