GI hormones/secretory products Flashcards

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1
Q

secrete gastrin

A

G cells of the antrum

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2
Q

actions of gastrin (3)

A

increase H+ secretion
increase growth of gastric mucosa
increase motility

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3
Q

3 potent stimulators of gastrin release

A

phenylalanine
tryptophan
Calcium

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4
Q

2 things that increase gastrin release

A

zollinger-ellison syndrome

chronic PPI use

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5
Q

secrete cholecystokinin

A

I cells of the intestine

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6
Q

3 actions of CCK

A

sphincter of do relaxation
gallbladder contraction
increased pancreatic secretions
decreased gastric emptying

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7
Q

secrete secretin

A

S cells of the duodenum

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8
Q

3 actions of secretin

A

increase pancreatic bicarbonate secretion
increase bile secretion
decrease gastric acid secretion

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9
Q

secrete somatostatin

A

D cells

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10
Q

main action of somatostatin

A

decrease everything

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11
Q

secrete GIP

A

K cells

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12
Q

exocrine function and endocrine function of GIP

A

exocrine- decrease gastric H+ secretion

endocrine- increase insulin release

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13
Q

GIP responds more rapidly to-

A

oral glucose (vs. IV), thus oral glucose is used more rapidly than IV

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14
Q

symptoms of VIPoma (3)

A

watery diarrhea
achlohydria
hypokalemia

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15
Q

action of motilin

A

produces migrating motor complexes during fasting state

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16
Q

motilin receptor agonist

A

erythromycin

17
Q

secrete intrinsic factor

A

parietal cells

18
Q

role of IF

A

binds B12, carries to terminal ileum for absorption

19
Q

secrete gastric acid

A

parietal cells

20
Q

regulation of gastric acid secretion (5)

A
increased:
Gastrin- Gq
ACH (M3) Gq
histamine (H2) Gs
decreased:
Somatostatin Gi
prostaglandins Gi
21
Q

secrete pepsinogen

A

chief cells

22
Q

what is alkaline tide?

A

describes the dumping of HCO3 into blood when stomach is producing H+

23
Q

2 substances that increase HCO3 secretion

A

secretin, CCK