GI hormones/secretory products Flashcards
secrete gastrin
G cells of the antrum
actions of gastrin (3)
increase H+ secretion
increase growth of gastric mucosa
increase motility
3 potent stimulators of gastrin release
phenylalanine
tryptophan
Calcium
2 things that increase gastrin release
zollinger-ellison syndrome
chronic PPI use
secrete cholecystokinin
I cells of the intestine
3 actions of CCK
sphincter of do relaxation
gallbladder contraction
increased pancreatic secretions
decreased gastric emptying
secrete secretin
S cells of the duodenum
3 actions of secretin
increase pancreatic bicarbonate secretion
increase bile secretion
decrease gastric acid secretion
secrete somatostatin
D cells
main action of somatostatin
decrease everything
secrete GIP
K cells
exocrine function and endocrine function of GIP
exocrine- decrease gastric H+ secretion
endocrine- increase insulin release
GIP responds more rapidly to-
oral glucose (vs. IV), thus oral glucose is used more rapidly than IV
symptoms of VIPoma (3)
watery diarrhea
achlohydria
hypokalemia
action of motilin
produces migrating motor complexes during fasting state
motilin receptor agonist
erythromycin
secrete intrinsic factor
parietal cells
role of IF
binds B12, carries to terminal ileum for absorption
secrete gastric acid
parietal cells
regulation of gastric acid secretion (5)
increased: Gastrin- Gq ACH (M3) Gq histamine (H2) Gs decreased: Somatostatin Gi prostaglandins Gi
secrete pepsinogen
chief cells
what is alkaline tide?
describes the dumping of HCO3 into blood when stomach is producing H+
2 substances that increase HCO3 secretion
secretin, CCK
