GI - Gastric Drugs

Question 1

Name a H2 receptor antagonists

Answer 1

Ranitidine
Nizatidine
Cimetidine (has some DDIs so not really prescribed)

Question 2

Name a proton pump inhibitor

Answer 2

Esomeprazole
Omeprazole
Lansoprazole

Question 3

How long do PPIs take to work, and for the pt to recover afterwards?

Answer 3

2-3 days for achlorhydria for healing ulcers

2-3 days after stopping drugs

Question 4

Name an antacid

Answer 4

Aluminium hydroxide

Question 5

Name a compound alginate

Answer 5

Alginic acid (Gaviscon)

Question 6

What is the MoA of alginic acid?

Answer 6

Combines with bicarbonate to make a barrier over the gastric acid to stop it from refluxing

Question 6

What is the MoA of antacids?

Answer 6

Reacts with the HCl to make a salt and water, therefore reducing the amount of acid in the stomach and increasing the pH

Question 8

What is the treatment pathway for GORD?

Answer 8

• Lifestyle e.g. avoid late meals, alcohol and chocolate, lose weight
• Antacids/ alginates
• H2RAs
• PPIs

Question 9

How do you treat H-pylori?

Answer 9

2 antibiotics and a PPI

Clarithromycin, amoxicillin, lansoprazole