GI Disorders Flashcards

1
Q

What are the different types of vomiting?

A
  • vomiting with retching
  • projectile vomiting
  • bilious vomiting
  • effortless vomiting
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2
Q

What can stimulate the vomiting centre?

A
  • enteric pathogens
  • intestinal inflammation
  • metabolic derangement
  • infection
  • head injury
  • visual stimuli
  • middle ear stimuli
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3
Q

What are features of vomiting with retching?

A
  • pre-ejection phase
  • pallor
  • nausea
  • tachycardia
  • ejection phase
  • retch
  • vomit
  • post-ejection phase
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4
Q

What are indications for a test feed?

A
  • palpation of ‘olive’ tumour
  • visible gastric peristalsis
  • projectile non-bilious vomiting
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5
Q

What is the management?

A
  • fluid resuscitations
  • Ramstedts pyloromyotomy
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6
Q

What are features of pyloric stenosis?

A
  • 4-12 weeks age
  • boys > girls
  • projectile non-bilious vomiting
  • weight loss
  • dehydration +/- shock
  • electrolyte disturbance
  • metabolic alkalosis
  • hypochloraemia
  • hypokalaemia
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7
Q

What are features of bilious vomiting?

A
  • always draw serious attention
  • usually due to intestinal obstruction
  • intestinal atresia
  • malrotation +/- volvulus
  • intussusception
  • ileus
  • Crohn’s disease
  • XR
  • contrast meal
  • laparotomy
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8
Q

What are features of effortless vomiting?

A
  • usually due to GORD
  • very common
  • self limiting + usually resolves
  • except; cerebral palsy, progressive neurological problems, oesophageal atrasia, generalised GI motility problem
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9
Q

What are the symptoms of reflux?

A
  • GI
  • vomiting
  • haematemesis
  • nutritional problems
  • failure to thrive
  • feeding problems
  • respiratory
  • apnoea
  • cough
  • wheeze
  • chest infections
  • neurological
  • Sandifer’s syndrome
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10
Q

What are the investigations for reflux?

A
  • exam
  • video fluoroscopy
  • barium swallow
  • pH study
  • oesophageal impedance monitioring
  • endoscopy
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11
Q

What is the treatment for reflux?

A
  • feeding advice
  • thickeners for liquid
  • appropriate amount, thickness of food
  • behavioural programme
  • feeding position
  • nutritional support
  • calorie supplements
  • exclusion diet (milk free
  • NG tube
  • gastrostomy
  • medical treatment
  • feed thickener- Gaviscon, Thick + Easy
  • prokinetic drugs
  • acid suppressing drugs
  • surgery
  • failure of medical treatment
  • Nissen fundoplication
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12
Q

What is the definition of chronic diarrhoea?

A
  • ≥ 4 stools per day
  • > 4 weeks
  • > 1 week: acute diarrhoea
  • 2-4 weeks: persistant diarrhoea
  • > 4 weeks: chronic diarrhoea
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13
Q

What are causes of diarrhoea?

A
  • motiltity disturbance
  • toddler diarrhoea
  • IBS
  • active secretions (secretory)
  • acute infective diarrhoea
  • IBD
  • malabsorbtion of nutrients
  • food allergy
  • coeliac disease
  • cystic fibrosis
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14
Q

What is osmotic diarrhoea?

A
  • movement of water into bowel to equal osmotic gradient
  • usually a feature of malabsorbtion
  • enzymatic defect
  • transport defect
  • mechanism of action of lactulose/movicol
  • usually with macro/microscopic intestinal injury
  • clinical remission with removal of causative agents
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15
Q

What is secretory diarrhoea?

A
  • usually toxin production
  • vibrio cholerae
  • e. coli
  • intestinal fluid secretion
  • active Cl- secretion via CFTR
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16
Q

What is motility diarrhoea?

A
  • toddler’s diarrhoea
  • IBS
  • congenital hyperthyroidism
  • chronic intestinal pseudo-obstruction
17
Q

What is inflammatory diarrhoea?

A
  • mixed
  • malabsorbtiondue to intestinal damage
  • secretory effects of cytokines
  • acceerated transit time in response to inflammation
  • protein exudate across inflamed epithelium
18
Q

What are the investigations for diarrhoea?

A
  • history
  • growth + weight gain
  • faecal analysis
  • appearance
  • stool culture
  • determination of secretory vs osmotic
19
Q

What are causes of fat malabsorbtion?

A
  • pancreatic disease
  • diarrhoea due to lack of lipase + resultant steatorrhoea
  • classically cystic fibrosis
  • hepatobillary disease
  • chronic liver disease
  • cholestasis
20
Q

What is coeliac disease?

A
  • gluten-sensitive enteropathy
  • wheat, rye, barley
  • 1% of western population
21
Q

What are signs of coeliac disease?

A
  • abdominal bloatedness
  • diarrhoea
  • failure to thrive
  • short stature
  • constipation
  • tiredness
  • dermatitis herpatiformis
22
Q

What are the screening test for coeliac disease?

A
  • serological screens
  • anti-tissue transglutaminase
  • anti-endomysial
  • anti-gliadin
  • concurrent IgA deficiency
  • duodenal biopsy
  • genetic testing
  • HLA DQ2, DQ8
23
Q

What is seen on histology of duodenal biopsy in coeliac disease?

A
  • lymphocytic infiltration of surface epithelium
  • partial/total villous atrophy
  • crypt hyperplasia
24
Q

What are the ESPGHAN/BSPGHAN guidelines criteria for diagnosis without biopsy?

A
  • symptomatic children
  • anti TTG > 10 X upper limitof normal
  • +ve anti-endomysial antibodies
  • HLA DQ2, DQ8 +ve
25
Q

What is the treatment for coeliac disease?

A
  • gluten-free diet for life
  • gluten must not bbe removed prior to diagnosis
  • in < 2 yrs, re-biopsy may be warranted
  • inc. risk of rare small bowel lymphoma if left untreated