GI - Diarrhoea Flashcards
Anti-motility drugs, bulk forming agents, other anti-diarrhoea drugs.
Give an example of an anti-motility drug.
Loperamide (imodium).
What is the mechanism of action of anti-motility drugs?
Opioid-like action on the gut, activate opioid receptors in enteric nervous system to inhibit acetylcholine release and decrease peristalsis. This increases time for fluid to reabsorb, increases anal tone and reduces sensory defecation reflex.
What is a contraindication and risk of anti-motility drugs?
IBD - can contribute to toxic megacolon.
Give an example of an anti-spasmotic drug.
Mebeverine.
What is the mechanism of action of anti-spasmotics?
Relieves spasm so reduced colonic hypermobility.
What is cholestyramine/Questran?
Bile acid sequestrant.
What is the use of bile acid sequestrants?
Bile salt induced diarrhoea in Crohn’s disease.
