GI - Acid Secretion Flashcards
PPIs, histamine 2 receptor antagonists
1
Q
Give an example of a PPI.
A
Omeprazole, lansoprazole.
2
Q
What is the mechanism of action of PPIs?
A
Bind to the H+/K+/ATPase of parietal cells and block it so it can’t secrete acid.
3
Q
What is the main side effects of PPIs?
A
Diarrhoea.
4
Q
When should PPIs be administered and why?
A
30-60 minutes before breakfast or the largest meal of the day as they have delayed onset of action.
5
Q
Give an example of a histamine 2 receptor antagonist.
A
Cimetidine, ranitidine.
6
Q
What is the mechanism of action of H2RAs?
A
Competitively blocks binding of histamine to H2 receptors, therefore reduces secretion of action by blocking stimulation of H+/K+/ATPase proton pump.
