GI Bacteria Flashcards
H.Pylori
Virulence?
Classification (microbiology)?
Low Virulence commensal in GIT
Gram negative
Pathology of H.Pylori
What is released?
- decreased somatostatin
- increased luminal gastric acid (as + gastrin)
- Urease; converts urea to ammonia (neutralises acid + protects H.Pylori)
- low HCO3- secretion
What diseases does H.Pylori cause?
PUD
Gastritis
Gastric carcinomas
How to diagnose H.Pylori?
Biopsy (stool antigen + C urea breath test as first line)
Treatment for H.Pylori
Triple therapy CAP
Clarythromycin
Amoxicillin
PPI
What is E.Coli a major player in?
In UTIs (UPEC)
What type of bacteria is E.Coli (microbiology)?
Gram negative, often commensal flora in GIT
Virulence of E.Coli
Same strains/’serotypes’ very virulent
What main symptom do they cause?
Diarrhoea (either watery or bloody)
Which strains cause watery diarrhoea?
ETEC, EAEC, EPEC
Which strains cause Bloody diarrhoea?
EHEC (h=haemorrhage)
What does serotype 0157:H7 cause?
Haemolytic uremic syndrome (causes haemorrhage diarrhoea + nephritic syndrome)
Treatment for E.Coli?
Often amoxicillin, or trimethoprim / nitrofurantoin
What type of bacteria is C.Difficile?
Microbiology
Gram positive (rods) spore forming bacteria
(do not require O2)
What is it mainly induced by and why?
With Abx : Ciprofloxacin, Co-amoxiclav, cephalosporins, clindamycin (Cs)
Gets rid of normal flora and lets C.difficile thrive
