GI Flashcards
Source of bleed causing melena
Upper GI
Source of bleed causing hematochezia
Lower GI
Rupture of the esophagus from repeating vomiting/retching
Boerhaave’s syndrome
Boerhaave’s syndrome
Rupture of the esophagus; life-threatening
Acute gastroparesis tx
Erythromycin
Chronic gastroparesis tx
Metoclopramide
2 MC sites of volvulus
- Cecum
- Sigmoid colon
“Currant jelly” stools and a sausage-like abdominal mass are associated with?
Intussesception
90% of Hirschsprung disease occurs in the…?
Rectosigmoid area
Adenocarcinoma of the small intestine MC occurs where?
- Duodenum
- Proximal jejunum
- Actual MC site is the Ampulla of Vater
Carcinoid syndrome consists of…?
- Flushing
- Diarrhea
- Hypotension
95% of Diverticulosis occurs where?
Sigmoid colon
Almost all CR cancers are what type?
Adenocarcinomas
MC locations of CR cancers
- 50% rectosigmoid region
- 25% cecum/ascending colon
CR cancer has a peak incidence at what age?
65 yo
Is Crohn’s disease patchy or continuous?
Patchy
Is Crohn’s disease transmural or superficial?
Transmural
MC locations of Crohn’s
- 40-50% in ileocecal region
- 30-40% in small bowel
Is UC patchy or continuous?
Continuous
Hallmark of ulcerative colitis
Bloody diarrhea with mucus
Caput medusa
- Superficial enlargement of umbilical veins
- Pathognomonic of portal hypertension
- Superficial enlargement of umbilical veins
- Pathognomonic of portal hypertension
Caput medusa
Significant labs in fatty liver disease
- AST»_space; ALT
- Really high TG
Excessive iron loading in the tissues due to a primary genetic defect
Hereditary hemochromatosis
Rare, autosomal recessive disorder characterized by excessive amounts of copper in the brain, liver, kidneys, and cornea
Wilson’s disease
Kayser-Fleischer rings in the eyes are associated with what?
Wilson’s disease
Wilson’s disease is caused by low levels of what?
Ceruloplasmin
Where are the stones in Cholelithiasis?
Gallbladder body
Where are the stones in Cholecystitis?
Cystic duct
Where are the stones in choledocholithiasis?
Common bile duct
Where would stones be that might cause pancreatitis?
Ampulla of Vater
Charcot’s triad consists of what and is associated with what?
- RUQ pain
- Jaundice
- Fever with chills
- -> Acute Cholangitis
RUQ pain, jaundice, fever with chills
Charcot’s triad
Gold standard to diagnose acute pancreatitis
CT abdomen
Prognosticator of acute pancreatitis mortality
Ranson’s criteria
Cullen sign
Blue umbilical region
Turner’s sign
Green/brown flanks
Common cause of “backpacker’s” diarrhea
- Cambylobacter
- Giardiasis
Common source of cambylobacter
Chickens
Gram (-) flagella
Cambylobacter
Gram (-) organism causing bile-colored diarrhea
Cambylobacter
Leading cause of food poisoning
Salmonella
Common sources of salmonella
Turkey, Duck, Chicken (TURKDUCKEN)
Watery diarrhea, occasionally with mucus and blood
Salmonella
Multiple, small volume, bloody, mucoid stools
Shigella
Moderate to severe diarrhea with 10-12 stools per day
E. coli 0157:H7
E. coli 0157:H7 tx
NO ANTIBIOTICS
Explosive stools with violent, repeated vomiting/retching
Staph aureus toxin
Major cause of traveler’s diarrhea
Enterotoxic E. coli
Virus responsible for gastroenteritis in most daycares
Rotavirus
Virus responsible for gastroenteritis in cruise ships
Norwalk virus
Get this from “pristine mountain streams”
Giardiasis
- Explosive, loose stools
- Flatulence
- Audible borborygmi
Giardiasis
Giardiasis tx
Metronidazole
Hernia lateral to the inferior epigastric vessels
Direct inguinal hernia
Hernia passes through the inguinal ring
Indirect
Fat-soluble vitamins
A, D, E, K
Drug that interferes with regeneration of vitamin K in the liver
Coumadin
Drug accelerates metabolism of vitamin B6
Isoniazid
Drug that reduces intestinal vitamin K synthesis
Penicillins
Drugs that cause impaired vitamin D metabolism
Phenytoin or Phenobarbitol
Drugs that affect folate metabolism
Sulfa
Major circulating form of D3
Calcidiol
Most potent physiological active form of D3
Calcitriol
Vitamin D is responsible for regulation of what other….things?
Calcium and phosphorus
Antioxidant in the lipid phase of cell membranes
Vitamin E
Function of Vitamin E
Antioxidant in the lipid phase of cell membranes
Factors that are dependent of vitamin K
2, 7, 9, 10, protein C and protein S
Vitamin B1 function
Plays a role in nerve conduction
Vitamin that plays a role in nerve conduction
Vitamin B1
Beriberi
Lack of Vitamin B1
Wet beriberi affects what system in the body?
CV system
Wernicke’s encephalopathy and Korsakoff’s psychosis are caused by what?
B1 deficiency
Amnesia and impaired learning caused by Vitamin B1 deficiency
Korsakoff’s psychosis
Role of vitamin B2
Essential for the conversion of Vitamin B6 to it’s active form (Riboflavin B2)
Function of biotin
Energy production
Function of Niacin
Energy production
Responsible for energy production
Biotin and Niacin
Pellagra
- Dermatitis, Diarrhea, Dementia
- Deficiency of Niacin
What kind of anemia can result from B6 deficiency?
Sideroblastic anemia
Function of vitamin C
- Collagen synthesis
- Carnitine biosynthesis (breaks down fats)
- Regenerates vitamin E
What’s responsible for regeneration of vitamin E?
Vit C
Why do we not worry about pantothenic acid deficiency?
It’s wide-spread in foods
Vit B9 is AKA ?
Folate
B9 works with B12 to form what?
Hgb
Folate deficiency causes?
Megaloblastic anemia
Absorption of B12 requires what?
intrinsic factor
B12 deficiency causes what?
Megaloblastic anemia and neuropathy
Creatinine is an energy molecule - no question
…..??
Role of CLA
Reduces fat by 3g/day
Obese BMI
> 30
“Mousy” urine odor associated with?
PKU