GI Flashcards
What is GERD
Reflux of stomach contents into esophagus
What leads to the sx of GERD
Breakdown of reflux barrier and poor clearance of aci
What causes GERD
Incompetent Barrier (LES relaxation, hiatial hernia, scleroderma)
Aggressive reflux
Reduced acid clearance in esophagus
Increased abdominal pressure
What are 4 common associated conditions of GERD
Sliding Hiatal Hernia
Tobacco and Alcohol
Scleroderma
Decreased Gastrin Production
Sx of GERD
Pyrosis Regurgitation Water Brash Dysphagia Hoarseness Globus Sensation Chronic Cough Asthma Chest Pain
What are common complications of GERD
Barrett’s Esophagus
Ulcers or Adenocarcinoma
Dental Caries
Dx of GERD
Trial of H2 blockers first
Endoscopy
pH Monitoring
Tx of GERD
Lifestyle Modification
H2 blockers, PPI, Antacids
Fundoplication if no relief
What are indications for surgical treatment of GERD
Failure of medical management
Esophageal Stricture
Pulmonary Insufficiency (nocturnal aspiration)
Barrett’s Esophagus (squamous epithelium transition to columnar due to reflux)
What is an Esophageal Stricture
Narrowing or tightness of esophagus causing problems in swallowing
What causes Esophageal Stricture
Ingesting Lye or caustic substances
Dx of Esophageal Stricture
EGD within 24 hours of ingestion to assess level of ulceration + contrast to rule out performation
Tx of Esophageal Stricture
Immediate: NPO + IV fluids + H2 blocker Don't induce emesis Medical: Shallow - Corticosteroids Moderate to deep - Abx (Penicillin or Gentamicin) Endoscopy every 2 years
What is surgical tx for Esophageal Stricture
Dilation: With Maloney Dilator/Balloon Catheter
Esophagectomy: With Colon interposition or gastric pull up
What is a Hiatal Hernia
Protrusion of GE junction through hiatus of diaphragm
What are 6 causes of Hiatal Hernia
Widened Hiatus Esophageal shortening Increased intra-abdominal pressure Autosomal Dominant Congenital Acquired (traumatic)
What are the 4 types of Hiatal Hernias
Type 1: Sliding Hernia
Type 2: Defect in phrenoesophageal membrane, leads to gastric fundus herniation
Type 3: Both GE junction and fundus herniate through hiatus
Type 4: Omentum/Colon/Small bowel present in hernia sack
Sx of Hiatal Hernia
Asymptomatic
Reflux symptoms
Dx of Hiatal Hernia
Upper Endoscopy
Tx of Hiatal Hernia
Tx for GERD sx
Surgical if severe
What is Zenker’s Diverticulum
False Pharyngoesophageal Diverticulum
Involves mucosa and submucosa at UES
Sx of Zenker’s Diverticulum
Dysphagia + Neck Mass + Hilitosis + Food regurgitation + Heartburn
Dx of Zenker’s Diverticulum
Barium Swallow
Tx of Zenker’s Diverticulum
Diverticulectomy Cricopharyngeal Myotomy (UES relaxation)
What is Leiomyoma
Benign smooth muscle tumor
Sx of Leiomyoma in Esophagus
Dysphagia
Dx of Leiomyoma in Esophagus
Barium Swallow: Will show filling defect
Esophagoscopy: CONFIRMS Dx
Ultrasound to confirm mass is intramural
Tx of Leiomyoma in Esophagus
Surgical Removal
Enucleation: Removal of mass without harm to surrounding tissues
Resection if low grade tumor
What are 3 forms of Intraluminal Masses
Mucosal Polyps, Lipomas, Myxofibromas
Sx of Intraluminar Masses
Dysphagia + Regurgitation + Weight Loss
Dx of Intraluminar Masses
Radiographs and Esophagoscopy
Tx of Intraluminar Masses
Esophagotomy and Repair
Sx of Esophageal Carcinoma
Dysphagia, first with solids then eventually with liquids
Weight Loss
Hoarseness if laryngeal nerve is damaged
Dx of Esophageal Carcinoma
Contrast XRAY
Upper Endoscopy with Biopsy
Tx for Esophageal Carcinoma
Radio Frequency Ablation and Endoscopic Mucosal Resection for low grade
Esophagectomy + Gastric pull-up or colon resection for invasive
What population is more likely to get Squamous Cell Carcinoma of Esoaphgus
African Americans and Chinese
Smokers, Alcoholics
Hot foods or bad oral hygiene
What population is more likely to get Adenocarcinoma of Esophagus
White men with GERD, usually final stages that eventually lead to Barrett’s Esophagus
What is Achalasia
Loss of peristalsis in lower esophagus + lower esophageal sphincter remains closed during swallowing
What causes Achalasia
Neurologic: Loss of Auerbach’s plexus, Vagus Nerve
Infectious: Chagas, but rare
Sx of Achalasia
Dysphagia
Regurgitation
Dx of Achalasia
Distal narrowing and proximal dilation of esophagus
Manometry: Motility study shows increased LES pressure thatdoes not relax
Xray with contrast: BIRDS BEAK
Tx of Achalasia
Surgical Myotomy
Bolloon Dilation
What is Diffuse Esophageal Spasm
Strong non-peristaltic contractions of esophagus + Normal Sphincters
Sx of Diffuse Esophageal Spasms
Chest pain with radiation to back, ears, neck, and jaw
Dx of Diffuse Esophageal Spasms
Manometry: Repetitive high-amplitude contractions
Xray with Contrast: Segmented Spasms/CORKSCREW Esophagus
Endoscopy
Tx of Diffuse Esophageal Spasms
Medical: Antireflux/CCB/Nitrates
Surgical: Long Esophagomytomy
What is Nutcracker Peristalsis
Hypertensive Peristalsis
Presents like Diffuse Esophageal Spasms but are very strong Peristaltic waves
Dx and Tx for Nutcracker Peristalsis
Manometry, Xray with Contrast, Antireflux Meds, Long Esophagomytomy
What is Peptic Ulcer Disease
Damage to gastric mucosal barrier causing erosion through submucosa or muscularis propria
Causes of PUD
H.Pylori
NSAIDS
Bile Reflux
Gastrinoma (Zollinger-Ellison Syndrome): Neuroendocrine tumor that secretes gastrin, leads to ulcers and diarrhea
Sx of PUD
Burning mid-epigastric stomach paid reduced by food or antacids
N/V, Hematemesis, Melena
Usually asymptomatic until severe
Dx of PUD
Upper GI Xray: Barim pooling at ulcer
Endoscopy if alarm sx present (weight loss, melena, mass)
H.Pylori Breath Test
Tx of PUD
H.Pylori Positive do Triple Therapy: Clarithromycin + PPI + Amoxicillin/Metronidazole if allergic
Triple Therapy usually done for 10-13 days
H.Pylori Negative do PPI or H2 blocker for 4-8 weeks
Sucralfate: binds in ulcer and protects for 6 hours
What are 5 surgical indications for PUD
Intractability Uncontrolled Bleeding Perforation Gastric Outlet Obstruction Malignancy
What is the most common type of Gastric Cancer
Gastric Adenocarcinoma: poor survival 90-95% are malignant
What are the 2 types of Gastric Adenocarcinoma
Intestinal Type: Glandular and well-differentiated found in Distal stomach
Diffuse Type: Poorly differentiated small cell infiltrating tumor of proximal stomach
What are risk factors for gastric adenocarcinoma
Older males High Salt Intake Smoked Meats Low Protein Vit. A and C Smoking
Sx of Gastric Adenocarcinoma
Epigastric Pain + Anorexi + Fatigue + Vomiting and Weight Loss
Palpable Lymph Nodes: Supraclavicular or Periumbilical
Dx of Gastric Adenocarcinoma
Upper GI Xray
Upper Endoscopy + Biopsy
Tx of Gastric Adenocarcinoma
Subtotal or Total Gastrectomy
Resection or Bypass + Radiotherapy
Adjuvant Chemotherapy: 5-FU/Leukovorin + Radiation
What is a Gastric Lymphoma
Uncommon with good prognosis
Sx of Gastric Lymphoma
Abdominal Pain + Early Satiety + Fatigue + Constitutional B Sx (Fevers, night sweats, weight loss)
Dx of Gastric Lymphoma
Endoscopy and Biopsy with Endoscopic US for staging
Tx for Gastric Lymphoma
Medical: Chemo + Radiation (CHOP: Cyclophosphamide + Hydroxyduanomycin + Oncovin + Prednisone)
Surgical: Gastrectomy
What is a Gastric Sarcoma
Uncommon Cancer that arises from mesenchymal cells
Sx of Gastric Sarcoma
Usually incidental until large and obstruction
Dx of Gastric Sarcoma
Immunohistochemical stain hows CD1117
Tx of Gastric Sarcoma
Surgical removal
Imatinim (Gleevac)
What is Gastric Dumping Syndrome
When ingested food passes through the stomach rapidly and enters small intestine largely undigested
What causes Gastric Dumping Syndrome
Gastric Bypass, Roux-en-Y Surgery
Sx of Early Dumping Syndrome
15-30 minutes after a meal
N/V, bloating, cramping, diarrhea, dizziness, and fatigue
Sx of Late Dumping Syndrome
1-3 hours after meal
Weakness, sweating, dizziness
Dx of Dumping Syndrome
Clinical
Tx of Dumping Syndrome
Avoid foods that cause it
Eat several small meals a day low in carbs, avoid simple sugars
What is Pyloric Stenosis
Hypertrophy of muscular layer of pylorus that obstructs the gastric outlet
What age group does Pyloric Stenosis usually present in
2 weeks to 2 months old
Usually males, caucasians
Sx of Pyloric Stenosis
Projectile vomiting in infants
May lead to dehydration, Hypochloremia + Hypocalcemia + Metabolic Alkalosis + Jaundice
Dx of Pyloric Stenosis
Olive Shaped mass at midepigastric region
Ultrasound: Thick Pylorus, muscular wall width
Upper GI Xray: Gastric retention, elongation/narrowing antrum, string sign
Tx of Pyloric Stenosis
Pyloromyotomy: Incision of the longitudinal and circular muscles of the antrum
What are 4 causes of Small Bowel Obstruction
Adhesions
Hernias
Malignancy
Gallstones/Crohn’s/Intussusception/Volvulus
Sx of Small Bowel Obstruction
Crampy Abdominal pain + N/V + Bloating
Inability to pass stool or flatus
Dx of Small Bowel Obstruction
Abdominal Xray: Dilated small bowel loops + Air-fluid levels
CT: Localizes obstruction
Tx of Small Bowel Obstruction
Conservative: IV Resuscitation + NG tube decompression
Surgical: If alarm sx (peritoneal signs + Leukocytosis + Fever + No Resolution)
What is Crohn’s Disease
Ulcerative changes from transmural inflammation especially in Ileum.
Rectum is usually spared
What causes Crohn’s Disease
Idiopathic
Increased colon cancer risk after 8-10 years
Sx of Crohn’s Disease
Abdominal cramping + Chronic diarrhea with or without blood/mucus
Constitutional sx
Fulminant: Bowel obstruction or ileus/acute abdomen/sepsis
Dx of Crohn’s Disease
CT or Barium Enema: Skip lesions + Cobblestoning of mucosa + Fistulas
Endoscopy with small bowel follow through (see short thickened mesentry + grayish pink discoloration + fat wrapping)
Tx of Crohn’s Disease
Diet Modification: Low Fiber
Low Risk: Corticosteroids + Azathiopurine
High Risk: Anti-TNF (Infliximab)
Bowel Resection
What is Meckel’s Diverticulum
Remnant omphalomesenteric duct, pouthc near ileocecal valve
Sx of Meckel’s Diverticulum
PainLESS Rectal Bleeding without fever, nausea, vomiting or diarrhea
Dx of Meckel’s Diverticulum
Radionuclide Scan: IV infusion of technitium-99m pertechnetate taken up by ectopic gastric mucosa
What are risk factors for Colorectal Cancer
Family Hx IBD and Polyps Age>50 Diet (high fat or low fiber, fruits, veggies, calcium) Lifestyle (Inactive, Obesity, Alcohol)
What is Familial Adenomatous Polyposis
More than 100 polyps in colon at a young age
Has 100% risk of Colon Cancer
What is HNPCC
No polyposis preceding cancer
One site of mutation leading to colon and extracolonic malignancy
What is the most common form of colorectal cancer
Adenocarcinoma
Sx of Colorectal Cancer
Blood in stools
Change in bowel pattern
Abdominal Pain
Sx of Right sided Colorectal Cancer
Bleeding: Melana, Iron Deficiency Anemia, Right sided mass
Sx of Left sided Colorectal Cancer
Obstruction: Change in bowel habits, blood in stools, cramping abdominal pain
Dx of Colorectal Cancer
Colonoscopy with bopisy
CEA to later evaluate for recurrence
CT for extent and mets
Tx of Colorectal Cancer
Curative: Surgery +/- chemo
Chemo: 5-FU for patients with positive LN or mets
Radiation: Pre-operative to shrink tumor
Palliative: Chemo, Diverting Ostomy, Pain Management
Discuss Colorectal Cancer Screening
Average Risk: 50 yrs
1st degree relative with CRC: 40yrs or 10yrs younger than dx
Ulcerative Colitis: 8 years after dx
Primary Sclerosing Cholangitis + UC: Time of dx
FAP: Age 10 + Prophylactic Colectomy
HNPCC: Age 20 or 10 yrs younger than dx relative
What risk does someone with FAP have of developing cancer vs. someone with HNPCC
FAP: 100%
HNPCC: 80%
What is a Carcinoid Tumor
Neuroendocrine Tumors of Appendix, Ileium, Rectum, Stomach, Colon
Sx of Carcinoid Tumor
Flushing, Heart Palpitations, Abdominal Cramping, Wheezing and SOB
Tx of Carcinoid Tumor
Excision
What is Diverticulosis
Not a true diverticula
It only involve 2 layers: Mucosa and Submucosa
Where is the most common site for Diverticulosis
Sigmoid Colon
What causes Diverticulosis
Low Fiber
Sx of Diverticulosis
Asymptomatic
LLQ pain, Bleeding, Point tenderness
Dx of Diverticulosis
Colonoscopy, but can’t do while there is active bleeding
CT Scan
Tx of Diverticulosis
High fiber diet
Fiber supplements
What is Diverticulitis
Inflamed diverticula secondary to obstruction/infection (Fecaliths)
Sx of Diverticulitis
Fever, LLQ pain, Leukocytosis
Dx of Diverticulitis
CT
Increased WBC
Tx of Diverticulitis
Clear liquid diet, Broad Spectrum Abx (Cipro, Bactrim, Metronidazole)
What are the categories of IBD
Ulcerative Colitis and Crohn’s Disease
What is Ulcerative Colitis
Diffuse, CONTINUOUS superficial ulcers restricted to the colon Starts distal (rectum) Involves Mucosa and Submucosa only
Sx of Ulcerative Colitis
LLQ pain, Colicky
Tenesmus, urgency
Bloody Diarrhea, hemeatochezia
Dx of Ulcerative Colitis
Colonoscopy: See uniform inflammation, sandpaper appearance, pseudopolyps
Barium Study shows Stovepipe sign (loss of haustral markings)
+P-ANCA
Tx of Ulcerative Colitis
Surgery is curative
What is a Sigmoid Volvulus
Twist or torsion of organ on pedicle due to long freely moveable sigmoid colon or mesentery
What causes a Sigmoid Volvulus
Sigmoid twists counterclockwise around mesenteric axis
Torsion causes bowel obstruction and ischemia
Sx of Sigmoid Volvulus
Abdominal Pain and Distension + Obstipation
Dx of Sigmoid Volvulus
Barium Enema: Bird beak twist
Abdominal Radiograph: Bent inner tube or Coffee Bean Sign
Tx of Sigmoid Volvulus
Sigmoidoscopic Decompression if non-strangulated
sigmoidectomy if non-decompressible
What are Hemorrhoids
Swollen and inflamed subepithelial veins of the rectum and anus
What causes Hemorrhoids
Prolonged straining during defecation
What is an internal Hemorrhoid and its sx
Anastomosis of superior rectal artery and rectal veins
NOT painful
Associated with bleeding, discharge, prolapse and pruritis
What is an external Hemorrhoid and its sx
Anastomosis of inferior hemorrhoidal arteries and veins below the dentate line
May cause acute swelling and pain
Tx for Hemorrhoids
Conservative: High fiber diet, increase water bulk laxatives all to decrease strain during defectation
Medical: Injection sclerotherapy, rubber band ligation, electrocoagulation
Surgical: Hemorrhoidectomy
What is an Anal Fissure
Linear shaped ulcer
Due to tear in anoderm
What causes Anal Fissures
Trauma to the anal canal during defectation
Sx of Anal Fissures
Painful tearing type pain
Blood on defectation
Dx of Anal Fissures
Visual Inspection
Tx of Anal Fissures
Sitz Baths Topical Anaesthetics Nitroglycerin Topical Botulinium Toxin CCB: Nifedipine or Diltiazem
What is a Pilonidal Cyst
Chronic gland infection from hair foreign body leading to infection
Tx of Pilonidal Cyst
Perianal hygiene and shaving or laser epilation of area to reduce hair getting stuck
Surgical I&D: For acute abscess
Bascom Closure Flap
What is an Anorectal Fistula
Palpable subcutaneous tract between the external opening and the anus
Often created by drained abscess
Tx of Anorectal Fistula
Fistulotomy (open a fistular tract)
What is Cholelithisis
Gallstones
What are most gallstones made of
Cholesterol
Can be Bilirubin or Calcium Bilirubinate
Sx of Gallstones
Infrequent episodes of epigastric/RUQ pain that radiates to Right Scapula
Dx of Gallstones
Ultrasound
Tx of Gallstones
Elective Cholecystectomy
What is Acute Cholecystitis
Persistent bile duct obstruction
What causes acute cholecystitis
Gallstones trapped in the duct passageways
Sx of Acute cholecystitis
Steady, Severe RUQ/Epigastric pain, radiation to right shoulder Leukocytosis
Postprandial N/V, Diaphoresis, Fever
Dx of Acute Cholecystitis
+ Murphy’s Sign
Ultrasound shows stones and wall thickening
HIDA scan
Tx of Acute Cholecystitis
Conservative: NPO, IV Fluids, Abx
Cholecystectomy: Usually within 72 hours of onset
What is a Choledochal Cyst
Congenital malformation of pancreaticobiliary tree
Sx of Choledochal Cyst
Intermittent jaundice, pain, abdominal mass
Dx of Choledochal Cyst
Ultrasound or Radionuclide scan
What is Choledocholithiasis
Stones in the common bile duct
Most come from gallstones but these can form without a gallbladder
Sx of Choledocholithiasis
Asymptomatic
RUQ pain, radiates to shoulder, intermittent obstructive jaundice, acholic stools, bilirubinemia
Dx of Choledocholithiasis
ERCP (Endoscopic Retrograde Cholangiopancreatography)
Tx of Choledocholithiasis
Small stones will pass spontaneously
Surgical: Common Bile Duct Exploration
Mechanical Extraction: Under Fluoroscopic Guidance
What is Cholangitis
Stones impacted within bile duct with inflammation behind the obstruction, leads to bacterial infection
Sx of Cholangitis
Charchot’s Triad: Fever and Chills, Jaundice, Frequent RUQ pain
Reynold’s Pentad: Above + Altered mental status, Hypotension
Dx of Cholangitis
Patient looks toxic, febrile, jaundice, hypotensive
Leukocytosis
Ultrasound: Bile duct dilation
Tx of Cholangitis
Empiric Abx + Urgent ERCP + Cholecystectomy + fluid and electrolyte resuscitation
What is Primary Sclerosing Cholangitis
Inflammation and fibrosis causing stenosis and obstruction of biliary tract that can lead to biliary cirrhosis and liver failure
Sx of Primary Sclerosing Cholangitis
RUQ pain, Painless Jaundice, Pruritis, Fatigue, N/V, Hepative failure
Dx of Primary Sclerosing Cholangitis
ERCP or Percutaneous Transhepatic Cholangiogram
Criteria: Thickening/Stenosis of biliary ducts, Rule out other factors, No primary liver disease
Tx of Sclerosing Cholangitis
Internal Biliary Drainage
External Biliary Drainage
What is Cholangiocarcinoma
Typically associated with gallstones
Typically Adenomas
Dx of Cholangiocarcinoma
ERCP or Percutaneous Transhpeatic Cholangiogram
CT: 50% have porcelain gallbladder
Tx of Cholangiocarcinoma
Surgical Resection
Whipple
What is Hepatocellular Carcinoma
Primary cancer of liver parenchyma
What causes Hepatocellular Carcinoma
Cirrhosis
Hepatitis/Alcoholic Liver Disease/Non-Alcoholic Fatty Liver Disease
Sx of Hepatocellular Carcinoma
Pain, weight loss, cachexia, mass, bruit or friction rub, sudden ascites
Dx of Hepatocellular Carcinoma
Ultrasound every 6 months Serum Alpha-Fetoprotein CT/MRI with contrast Leukocytosis/Anemia Biopsy
Tx of Hepatocellular Carcinoma
Surgical Resection
Tx chronic viral hepatitis
Liver Transplant
What is the most common site for Mets
Lymph Nodes followed by Liver
What is Pancreatitis
Inflammation of the pancreas
What causes Pancreatitis
Alcohol Abuse
Biliary Tract Disease (gallstone pancreatitis)
Congenital Abnormalities and Latrogenic
Sx of Acute Pancreatitis
Mild abdominal discomfort, with eventual shock, hypotension, and hypoxemia
Epigastric pain that radiates to back
What are the following signs related to Acute Pancreatitis:
Turner’s Sign
Cullen’s Sign
Turner’s Sign: Flank Ecchymosis when blood extends into tissues
Cullen’s Sign: Periumbilical Ecchymosis from blood traveling along falciform ligament
Dx of Acute Pancreatitis
Serum Amylase: 200-500 in Alcoholic Pancreatitis
Amylase:Creatinine Clearance
Serum Lipase: Elevated
Ultrasound and CT is Diagnostic
Tx of Acute Pancreatitis
NPO + IV Fluids ERCP Fluids, Pain Management, Enteral Feeding NG tube Abx
What is Chronic Pancreatitis
Unrelenting sx of inlammation and fibrosis and ductal calcifications
Leads to both exocrine and endocrine failure
What causes Chronic Pancreatitis
Alcohol Abuse
Prolonged duration of acute causes
Sx of Chronic Pancreatitis
May eventually lead to glucose intolerance in diabetics
Common bile duct or duodenal obstruction form calcifications
Tx of Chronic Pancreatitis
Analgesia/Pain Meds
Endocrine Hormone Replacement
Exocrine (Lipase and Amylase) Replacement
Smaller meals, low fat content, elimination of smoking and alcohol, enzyme replacement, vitamins
Surgery
What is a Pancreatic Adenocarcinoma
4th most common cause of cancer
Increased risk with smoking, obseity, diet, and hereditary polyposis syndrome
Sx of Pancreatic Adenocarcinoma
Vague epigastric pain, weight loss, back pain
Thrombophlebitis (inflammation of wall of vein)
HEAD of pancreas is the most common site
Dx of Pancreatic Adenocarcinoma
Chemo: 5-FU + Gemcitabine
Intraoperative Radiotherapy
Whipple Procedure
What is a Direct Hernia
Medial to epigastric vessels
Goes directly through Hasselbach’s Triangle through abdominal and inguinal canal
What is an Indirect Hernia
Lateral to epigastric vessels
Passes through internal inguinal ring
5x more common!
Tx for Inguinal Hernia
Surgery: Return hernia contents to peritoneal cavity, Ligate the base of hernia sac, Tighten internal ring and repair abdominal wall
What is Bariatric Surgery
Weight loss surgery for morbid obseity
What are indications for Bariatric Surgery
BMI>40 or BMI>35 with co-morbidities (obesity hypoventilation syndrome/cardiopulmonary problems/Diabtes)
What are contraindications for Bariatric Surgery
Superobesity (BMI>50)
Pyschiatric Illness
Lack of motivation or understanding
Age>60
What is a Roux-en Y Gastric Bypass
Stomach is divided and attached to the small intestine about 50-60cm distally leaving a “roux limb” that drains all bile, pancreatic, and stomach enzymes
What are complications that can arise with Roux-en Y Gastric Bypass
Anastomotic Stricture Marginal Ulcer Anastomotic Leak Dumping Syndrome Gallstone Formation Vitamin and Mineral Deficiency (Folate/B12/Iron/Calcium)
What is a Lap Band
Laproscopically placed band around the stomach that can be adjusted post operatively
What are complications that can arise with a Lap Band
Erosions
Stenosis
Slippage of the band
What are results of Bariatric Surgery
50-70% of excess weight is lost in the first year
70-80% of excess weight is lost in the next 3 years
What results with Vitamin C Deficiency
Scurvy
Bleeding, Impaired Wound Healing
What results in Vitamin E Deficiency
Hemolytic Anemia
What results in Vitamin A Deficiency
Problems with vision
Night Blindness, Bitot Spots, Corneal Xerosis
What results with Niacin Deficiency
Pellagra
4 D’s: Dermatitis, Diarrhea, Dementia, Death
What results with Vitamin B6 Deficiency (Pyridoxine)
Peripheral Neuropathy
Seborrheic Dermatosis
Glossitis
Cheilosis