GI 3b (IBS/IBD)

Question 1

Eluxadoline

Answer 1

Treats IBS with Diarrhea
Mu and K Opioid Receptor Agonist
Delta Receptor Antagonist

Question 2

Linaclotide

Answer 2

Treats IBS with Constipation
Synthetic Peptide
Guanylate Cyclase C Receptor Agonist
- Increases cGMP and Cl- Secretion

Question 3

Prednisolone

Answer 3

Glucocorticoid
Reduce Inflammation in IBS/IBD

Question 4

Budesonide

Answer 4

Glucocorticoid
Reduce Inflammation in IBS/IBD

Question 5

Methotrexate

Answer 5

Anti-inflammatory
Inhibits DHFR and DNA synthesis

Question 6

Sulfasalazine

Answer 6

Anti-Inflammatory Agent
Reduce inflammation by:
- Decreasing leukotriene production
- Slowing neutrophil movement
- Decreasing superoxide generation

Question 7

Cyclosproine

Answer 7

Immunosuppressant
Inhibits Calcineurin and IL-2 synthesis

Question 8

Azathioprine

Answer 8

Immunosuppressant
Converted into Mercaptopurine Blocks purine/DNA synthesis

Question 9

Mercaptopurine

Answer 9

Immunosuppressant
Metabolized from Azathioprine
Blocks purine/DNA synthesi

Question 10

Infliximab

Answer 10

Chimeric Neutralizing Antibody
Inhibits TNFa

Question 11

Adalimumab

Answer 11

Humanized Monoclonal Antibody
Inhibits TNFa

Question 12

Golimumab

Answer 12

Humanized Monoclonal Antibody
Inhibits TNFa

Question 13

Vedolizumab

Answer 13

Humanized Monoclonal Antibody
Inhibits ⍺4β7 Integrin on
T-helper Lymphocytes
Preventing them from interacting with MCAM-1

Question 14

Ustekinumab

Answer 14

Humanized Monoclonal Antibody
Targets p40 subunit of IL-12 and IL-23 and blocks the cytokine from binding to its receptor