GI Flashcards
Dysphagia
Difficulty swallowing
Physiology or anatomical abnormalities
Needs prompts evaluation
Oropharyngeal dysphagia
Involves dysfunction in the oral, pharyngeal, and laryngeal structures
Transfers dysphagia
Inability to initiate a swallow or transfer of food from the mouth to esophagus
Coughing, choking, nasopharyngeal regurgitation, aspiration, retained food in mouth after swallowing
Esophageal dysphagia
Sensation of food getting stuck in the esophagus several seconds after initiating swallow
Structural causes of dysphagia
More common in esophageal
Due to cricopharyngeal bar, zenkers divierticulum, cervical webs, oropharyngeal tumor, osteophytes, skeletal abnormalities, congenital
Functional causes of dysphagia
More common in oropharyngeal
Can be iatrogenic from medication side effect, post surgical muscle problem, radiation, corrosives/infectious from diphtheria, Lyme disease, botulism, Mucositits (herpes, CMV, candida)/metabolic from amyloidosis, cushings, thryoidtoxicosis, Wilson’s disease/myopathic from connective tissue disease, MG, polymyositits, sarcoidosis, paraneoplastic syndrome/neurologic from brain stem tumor, head trauma, stroke, CP, GB, huntingtons, MS, polio, post polio syndrome, TD, ALS, PD, dementia
Swallowing phases
Oral-chewing , CN 5, 6,9, 12
Pharyngeal-CN 5, 9, 10, sensory impulse to brainstem for involuntary swallow
Esophageal -peristalsis and UES closes
Issues in each stage
Oral- pocketing, spillage; difficulty chewing
Pharyngeal- delayed swallow, failure to airway protect, nasal or oral regurg, residue remaining
Meds that can cause issues with swallowing
Xerostomia- antidepressants, antispasmodic, anti hypertensives, anticholinergics, antihistamines; bronchodilators, sedatives
Mucosal injury- fosamax, tetracycline, NSAIDs, potassium, ferrous sulfate
Lower esophageal sphincter pressure-theophylline, nitrates, CCB, BB, HRT; anticholinergics
Dysphasia diagnostics
Modified barium swallow
Cineesophagram
Oropharyngeal-videofluoroscopy, nasopharyngolaryngoscopy, fiberoptic endoscopic swallow eval
Esophageal-barium esophagram
Both- upper endoscopy
Management of dysphagia
Oropharyngeal-swallow rehab, thick liquids, hand feeding
Achalasia- surgical or endoscopy myotomy, injection of lower sphincter with Botox
Spastic motility disorder-CCB, PDI
Strictures- dilation
Surgery if structural
Non oral feedings if aspiration is occurring
Dyspepsia
Heartburn, chronic or recurrent upper abdominal pain with fullness, epigastric, pain or epigastric burning
More common and peptic ulcer disease, Gerd biliary colic medication induced
Consider prompt endoscopy and older adult because of increase rate of organic disease like cancer
Can be medication induced like with alcohol/steroids NSAIDs erythromycin , theophylline
H pylori, cancer
Perform H pylori testing on all patients either using a breath, test or fecal antigen or can do biopsy if doing endoscopy
Patient with large or non-healing ulcer should have a biopsy
Patient to her negative for H. pylori. Should try two months worth of PPIs.
Patient with functional dyspepsia trial of PPI
Patient with normal upper Endo consider further testing like abdominal imaging and gastric emptying study
NSAID induced gastric complications
Most common adverse effects are this Pepsi gastritis, duodenitis, and peptic ulcer disease
Risk factors include those over 65, high dose, prior history of peptic ulcer disease, two or more concurrent use of NSAIDs, use of NSAIDs with an anticoagulant steroid anti-platelet or SSRI and the presence of H pylori
Interact coated pills can seem to help but does not protect against G.I. bleeding
Can consider switching to an NSAID that only inhibits cox too, but then you have a higher risk of cardiovascular events
Can consider use a PPI and misoprostol in those who require and NSAID therapy
Gerd
Symptoms are complications, resulting from reflex of gastric contents into the esophagus beyond the oropharynx, nasopharynx larynx or lungs
Increases with age and then decreases after age 69
Equal prevalence across all genders and ethnic groups
Common in those who are overweight or obese with a BMI greater than 25
Causes include primary inappropriate, spontaneous relaxation of the LES, normal pressure 10-30, patients have less than 10, hiatal hernia, alcohol, caffeine, high fat foods, tomatoes, onions, citrus, chocolate
Meds can also increase risk, anticholinergics, beta blockers, calcium channel, blockers, diazepam, estrogen, nicotine, progesterone, and theoohylline
GERD patho
For probable factors
Transient LES relaxation
Low pressure
Decreased ability of the esophagus to clear itself of material
Decrease gastric emptying
Extent a coal injury is related to length of time gastric context are in contact with the esophagus
GERD clinical presentation
Older adults with long standing, Gerd can have atypical symptoms, such as dysphasia, odynophagia, vomiting , may have accompanying heartburn, epigastric, pain, nausea, bloating, asthma, cough, voice changes
Can mimic MI**
Can mimic asthma***
Water brash- salty tasting good in mouth
Symptoms usually are precipitated by food occur within one hour of eating, especially a large meal
Which of the following is not a risk factor for dyspepsia and GERD
Secondary job
Gerd is best described as
A chronic disease with relapsing symptoms
GERD DX
Empiric trial of PPI’s
Upper endoscopy -for those with new symptoms and patient safety, older unsuccessful therapy, warning science long-standing symptoms of recurrent continuous treatment dysphasia
24 hour ambulatory esophageal pH testing
Prolonged pH monitoring for 48 to 96 hours using a wireless pH capsule
Esophageal manometry
GERD management
Weight loss
Elevating head of bed and avoiding meals 2 to 3 hours before bedtime
Avoiding medication’s
Avoiding food triggers
Antacids over-the-counter histamine two blockers
Treat with PPIs for 48 weeks if a eight week there is no follow up drug can be titrated to be twice a day
Can do surgery patients have a large hiatal hernia
Smoking sensation
Low-fat diet
Small meals
Stay upright two hours post meal
Can do antacids with lifestyle change histamine two blockers like Pepcid Zantac PPIs , Reglan, but not a drug of choice
Complications of GERD
Esophageal structures
Hemorrhage
Perforation
Chronic bleeding, iron deficiency, anemia
Bears esophagus, which can lead develop to cancer
The core pathology of Gerd is
Impaired structure and function of the lower esophagus
Which lifestyle modification has the strongest evidence support in reducing dyspepsia and Gerd symptoms?
Weight loss and head of bed elevation
Which of the following Gerd symptoms has the greatest negative impact on patient’s quality of life
Nighttime heartburn
Adverse G.I. effect with NST may increase with concurrent use of
SSRIs