GI

Question 1

H2 Blockers

• Cimetidine
• Ranitidine
• Famotidine

Answer 1

Question 2

PPIs

Answer 2

Question 3

Misopristol

Answer 3

Question 4

Orlistat

Answer 4

Question 5

Antacids

• aluminum – constipation
• magnesium – diarrhea

Answer 5

Question 6

Bismuth & Sucralfate

Answer 6

Question 7

Octreotide

Answer 7

Question 8

Diphenoxylate vs. Loperamide

Answer 8

Question 9

Adverse effects of opioid antidiarrheals:

Answer 9

Diphenoxylate
* dependence risk (crosses BBB)– combine with atropine to prevent abuse
Loperamide
* QT prolongation – Torsade de Pointes

Question 10

Ondansetron

Answer 10

Question 11

Metoclopramide

Answer 11

Question 12

Bulk-forming laxatives

• Psyllium
• Methylcellulose

Answer 12

Question 13

Senna

Answer 13

Question 14

Docusate

Answer 14

Question 15

H. Pylori - triple therapy

Answer 15

1. amoxicillin
2. clarithromycin
3. PPI

Question 16

PPI adverse effects

Answer 16

1. Bone fracture risk – decreased get Ca2+ absorption
2. p450 inhibitor – Rx interactions
3. Increased infection risk – C. diff

Question 17

Why is a patient in the weight loss clinic on Orlistat Rx experiencing easy bruising/bleeding?

Answer 17

Vitamin K deficiency (fat soluble vitamins malabsorption: ADEK)

Question 18

Most testable adverse effect of Octreotide:

Answer 18

Formation of gallstones
* Inhibition of CCK
* Increases bile stasis

Question 19

Torsade de Pointes & QT-prolongation

Answer 19

• High risk of mortality
• Rx = IV Magnesium Sulfate (Mg2SO4)

Question 20

Weird adverse effect of Senna? Classic vignette: Young woman who abuses a laxative to lose weight, and surgeon incidentally finds this during abdominal surgery

Answer 20

Melanosis Coli
* Harmless black coloration of the colon
* observed on microscopy

Question 21

Aprepitant

Anti-emetic for chemotherapy-induced nausea and vomiting

Answer 21