Anti-epileptics

Question 1

Ethosuximide

Answer 1

Question 2

Levetiracetam

Answer 2

Question 3

Gabapentinoids

Answer 3

Question 4

Valproic Acid

Answer 4

• Block Na+ channels
• Increased GABA signaling in the brain

Question 5

Carbamazepine

Answer 5

Question 6

What does carbamazepine essentially do?

Answer 6

Stop action potentials.

Question 7

Lamotrigine

Question 8

SIADH - side effect of carbamazepine

Answer 8

• Syndrome of inappropriate ADH secretion
• Body makes too much ADH&raquo_space; too much water is reabsorbed
• Dilution of blood & hyponatremia

Question 9

Monitor which enzymes should be monitored in patients taking carbamazepine?

Answer 9

Liver enzymes. Can occasionally cause hepatotoxicity.

Question 10

Antiepileptics that can be used for Bipolar Disorder:

Answer 10

1. Valproic Acid
2. Carbamazepine
3. Lamotrigine

Question 11

Barbiturate names

Answer 11

• Phenobarbital
• Thiopental

Question 12

Barbiturates – main thing

Answer 12

Increases GABA signaling:

• Increases the duration of Cl- channel remain open in response to GABA signaling
• (as opposed to Benzodiazepines that increase the frequency of Cl- opening)

Question 13

Barbiturates (mechanism)

Answer 13

Question 14

Barbiturates (clinical use)

Answer 14

Question 15

Which drug class is preferred for treating seizures in babies?

Answer 15

Barbiturates

Question 16

Topiramate

Answer 16

Question 17

Topiramate can be used in the prophylaxis of what condition?

Answer 17

Migraines.

Question 18

What strange side effect should be monitored in patients taking Topiramate?

Answer 18

The formation of kidney stones.

Because it depletes Citrate in the urine&raquo_space; leading to stone precipitation.

Question 19

Vigabatrin

Answer 19