GI Flashcards
What is inflammatory bowel disease?
An umbrella term for the two main diseases causing inflammation of the GI tract.
What are the two main causes of IBD?
Ulcerative colitis and Crohn’s disease
What is Crohn’s diease?
Transmural inflammation of the GI tract (anywhere from mouth to anus).
Where is the most commonly affected area of Crohn’s?
Terminal ileum and Colon
Describe the epidemiology of Crohn’s?
- Has a peak onset in early life (20-40 years).
- More common in female than male
What genetic mutations can cause Crohn’s?
CARD15 and NOD2 mutation
What pathogens can cause Crohn’s?
- Mycobacterium paratuberculosis,
- Listeria
- Pseudomonas
What is thought to cause Crohn’s disease?
- Immune system is thought to be triggered by a pathogen. These pathogens get through the wall due to defect
- This causes the immune system to target the foreign pathogen. The immune cells invade deep into the mucosa and organise themselves into granulomas eventually forming ulcer.
- These ulcers go through all layers known as TRANSMURAL this occurs in patches known as skip lesions
What is the endoscopic appearance of Crohn’s?
Cobblestone appearance
What are the signs of Crohn’s?
- Abdominal tenderness
- Fever
- Mouth ulcers
- Rectal examination will show blood, skin tags, fissures and fistulas
What are the symptoms of Crohn’s?
- Weight loss
- Diarrhoea
- Abdominal pain (most common in RLQ where the ileum is)
- Lethargy and malaise also symptom
What are the investigations for Crohn’s?
- Faecal calprotectin (released by intestines when inflamed)
- C- reactive protein is a good indication of current inflammation
What is the diagnostic investigation for Crohn’s and what will it show?
Colonoscopy- will show mucosal inflammation (deep ulcers, skip lesions and cobblestone appearance)
Histology will show transmural inflammation with granulomas and goblet cells
What is the management for inducing remission in Crohn’s?
- Elemental diet (nutrients in pre digested form)
- First-line is glucocorticoids e.g., prednisolone and hydrocortisone)
- Immunosuppressants- should not be used alone
- Biological therapy
- Adjunct use antibiotics
What are some immunosuppressants used to treat Crohn’s? Levels of what should be measured before using them?
- Azathioprine
- Methotrexate
- Mercaptopurine
Levels of Thiopurine methyltransferase should be measured before using
What are the biological therapies used to treat Crohn’s?
Infliximab and Adalimumab
How would you maintain remission in Crohn’s?
- First line= Azathioprine or mercaptopurine
- Second line- Methotrexate with Infliximab
When and what surgery could be used to treat Crohn’s?
- When distal ileum is inflamed can surgically resect the area to prevent flare ups
- Also used to treat strictures and fistulas
What are the key things to remember for Crohn’s?
NESTS
N- No blood or mucus
E- entire GI tract
S- Skip lesions
T- Terminal ileum and transmural
S- Smoking is a big risk factor
What is Ulcerative colitis?
A type of IBD that typically involves the rectum and variable lengths of the colon. Will never spread beyond the ileocecal valve
Describe the epidemiology of UC?
- Bimodal peak at 15-25 and 55-70
- More common in non-smokers
What is the gene implicated in UC?
HLA-B27
What are some other risk factors for UC?
- Non smoker
- NSAIDs
- Chronic stress/depression
Describe the pathophysiology of UC?
- Ulcers tend to form along the inner surface or lumen of the large intestine and rectum
- Thought to be autoimmune in nature cytotoxic T cells attack the lining of the colon
- Also thought that patients have higher proportion of gut bacteria that release sulphides