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GI Flashcards

1
Q

Linaclotide (linzess)

A
  1. IBS-C (if peg not working)
  2. Activates guanylate Cyclase —> stimulates cGMP —> increase intestinal fluid/motility
  3. Similar drug: plecanatide (trulance)
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2
Q

LA grade b esophagitis

A

Atleast 1 mucosal break > 5mm long but not continuous between the tips of adjacent mucosal folds

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3
Q

LA grade c esophagitis

A

Atleast 1 mucosal break that is continuous between the tips of the adjacent mucosal folds but no circumferential

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4
Q

La grade d

A

Mucosal break that involves Atleast 3/4 luminal circumference

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5
Q

La grade A esophagitis

A

One or more mucosal breaks each < 5mm in length

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6
Q

Eluxadoline (viberzi)

A
  1. Abdominal pain and IBS-D

2. Binds to opiate receptors and inhibits peristalsis

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7
Q

Lubriprostone (amitiza)

A
  1. IBS-C

2. Activate CIC-2 chloride channels which increases intestinal fluid secretion/motility

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8
Q

4 medications to treat abdominal pain in IBS

A
  1. Hysocyamine (levsin): anti-spasmodic
  2. Dicyclomine (Bentyl): AS + AC
  3. SSRI (C)
  4. TCA (D)
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9
Q

IBS-D (4 medications)

A
  1. Loperamide
  2. Eluxadoline
  3. Rifaximin
  4. TCA (abdominal pain)
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10
Q

Rifaximin

A
  1. Global symptoms for IBS-D

2. Inhibits bacterial RNA synthesis by binding to bacterial DNA-Dep RNAP

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11
Q

IBS-C (3 medications)

A
  1. Lubriprostone (amitiza)
  2. Linaclotide (linzess)
  3. SSRI (abdominal pain)
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12
Q

Forrest 2A

A

Non-bleeding visible vessel

-endoscopic therapy and high dose PPI

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13
Q

Forrest 2B

A

Adherent clot

  • no recc for/against endoscopic therapy
  • high dose PPI
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14
Q

Forrest 2C

A

Flat pigmented spot

-standard PPI

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15
Q

Forrest 3

A

Clean based ulcer

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16
Q

Forrest 1A

A

Active spurting bleeding

17
Q

Forrest class 1B

A

Active oozing bleeding

18
Q

Type 1 biliary cyst (4 subtypes)**

A

Cystic or fusiform dilation if CBD
A. Cystic dilation of CBD, part/all of the CHD and EH portions of the left/right hepatic ducts *
B. Focal segmental dilation of an EH bile duct (typically CBD)
C. Smooth fusiform, dilation of all the EH bile ducts *
D. Cystic dilation of common and cystic duct

19
Q

Type 2 biliary cysts

A

True diverticula of the EH bile ducts

20
Q

Type 3 biliary cysts (2 types)

A

Choledochoceles (Intraduodenal portion of the distal CBD)
A. Bile duct and pancreatic duct enter cyst, which then drains into duodenum at separate orifice
B. Diverticulum of the intraduodenal CBD or intra-ampullary common ductal channel

21
Q

Type 4 biliary cysts (2 types)**

A

Multiple cysts
A. Both IH and EH cystic dilations
B. Multiple EH cysts

22
Q

Type 5 biliary cyst

A

One or more cystic dilations of the IH ducts

-presence of multiple saccular or cystic dilations is known as caroli disease

23
Q

Type 6 biliary cyst

A

Isolated cystic dilations of the cystic duct

GI (3 decks)

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