GI Flashcards
Causes of upper GI bleed?
- Peptic ulcer
- Esophageal
- Stress ulcers
- Mallory-Weiss tear
- Cancer
*~80% of GI bleeds are upper and are more dangerous
Causes of lower GI bleed?
- Diverticulosis
- AVMs
- Tumors
- Radiation
- Colitis
- Inflammation (Crohn’s)
- Infection (c diff, ecoli)
Reduces splanchnic blood flow, gastric acid secretion, and GI mobility.
Octreotide (Sandostatin)
Removes nitrogenous materials (blood) out of gut to prevent ammonia conversion which is important in liver disease.
Osmotic laxatives (sorbitol)
Why might beta blockers be given for GI bleed?
They constrict mesenteric portal venous flow.
What do you do if esophageal balloon is causing respiratory distress?
Cut the balloon
What are the exocrine functions of the pancreas?
-Secretes bicarb (to neutralize stomach acid), H2O, Na, K, digestive enzymes (trypsin, amylase, lipase)
What are the endocrine functions of the pancreas?
- Alpha cells: recreate glucagon
- Beta cells: secrete insulin
- Delta cells: inhibit recreation of above
Diffuse inflammation, destruction, and auto-digestion of the pancreas from premature activation of exocrine enzymes.
- Up to 6L of fluid may be recreated into interstitial spaces.
- Results in SIRS
Pancreatitis
What are complications of acute pancreatitis?
Atelectasis left lower lobe, left pleural effusion, bilateral crackles, ARDS (phospholipase A released which kills type II alveolar cells -> decrease surfactant)
What are the signs and symptoms of acute pancreatitis?
- Pain radiates to all quadrants
- Rigid abdomen
- No rebound tenderness
- Increase WBC
- Increase amylase (peaks in 4-24 hours, returns to normal in 4 days)
- Increase lipase (stays elevated longer than amylase)
- Decrease calcium (used for autodigestion)
- Increase blood sugar (beta cell injury)
Bluish discoloration and ecchymosis of periumbilical area caused by intraperitoneal bleeding.
Cullen’s Sign
Forms from digested blood and tracks around the abdomen from the inflamed pancreas
Methemalbumin
-Happens in acute pancreatitis
Bluish discolaration of flanks
Turner’s Sign
-Present in hemorrhagic pancreatitis
The more criteria present, the more severe the acute pancreatitis and increased morbidity
Ranson’s Criteria
At admission: -Age >55 -WBC >16 -Glucose >200 -LDH >350 AST >250
During next 48 Horus:
- Hct decreases to >10
- BUN increases >5
- Fluid sequestion >6
- Ca <8
- PaO2 <60
- Base deficit >4