GGT Flashcards
Involved in the transfer of the gamma glutamyl from gamma glutamyl peptides to amino acids, H2O2 and other small peptides
Gamma Glutamyl Transferase
Involved in peptide and CHON synthesis, regulation of tissue glutathione levels, transport of amino acids across cell membrane
Gamma Glutamyl Transferase
Tissue source
kidney
brain
prostate
pancreas
liver
Tissue source with highest concentration
liver
This is found in px. taking enzyme inducing drugs like ___
warfarin,
phenobarbital
phenytoin
GGT levels may indicate alcoholism particularly
Chronic alcholism
Diagnostic significance
- Hepatobiliary disorders
- Patients taking enzyme inducing drugs like warfarin, phenobarbital, phenytoin
- Alcoholism
- Acute pancreatitis and diabetes mellitus
GGT method
Szasz Method
Szasz Method
Substrate
L-Y-glutamyl-p-nitroanilide
Szasz Method
indicator reaction
production of p-nitroanilide or 5-amino-2-
nitrobenzoate
Principles of the Method
The rate of formation of _____ is measured as an increase in the absorbance which is proportional to the GGT activity in the sample
5-amino 3-nitrobenzoate
Reference Range
Men
6 - 55 U/L
Chromogenic product is produced and measured at ___
405 nm
Reference Range
Women
5 -38 U/L
Expected Range
CN
44.3-63.7 U/L
Expected Range
CP
212.0 - 305.3 U/L
Concentration
x 1158
