Gestational Trophoblastic Disorders

Question 1

Define GTD

Answer 1

a rare condition that occurs due to abnormal proliferation of trophoblastic cells inside the uterus, after conception

Question 2

What secretes HCG?

Answer 2

Trophoblast

Question 3

GTD risk factors?

Answer 3

Teens, over 35, previous molar/history, or of Asian origin

Question 4

Clinical presentation of GTD

Answer 4

Irregular uterine bleeding, excessive uterine enlargement, hyperthyroidism

Question 5

What imaging suspects a molar pregnancy, and what confirms?

Answer 5

Ultrasound suspects it, and Histology confirms it

Question 6

So what would a complete Mole look like via ultrasound

Answer 6

A snowstorm or a Punch of grapes appearance.

Question 7

Management of molar pregnancy?

Answer 7

Evacuation of the uterus via Suction Curettage.

Question 8

A complete hydatiform mole is characterized by purely paternal, or maternal chromosomes?

Answer 8

Paternal

Question 9

A partial mole is most commonly diagnosed as?

Answer 9

A missed miscarriage

Question 10

Why is medical management avoided in molar pregnancy?

Answer 10

Risk of disseminating trophoblastic tissue

Question 11

Anti-D immunoglobulin should be given after molar pregnancy evacuation in which patients?

Answer 11

Rh-negative women only.

Question 12

How long does hCG monitoring continue after normalization for a complete mole?

Answer 12

6 months

Question 13

A patient with a partial mole can discontinue hCG monitoring once…?

Answer 13

She has 2 consecutive normal hCG levels, four weeks apart

Question 14

What is the risk of recurrence of molar pregnancy in the future?

Answer 14

1%.