Gestational Trophoblastic Diseases Flashcards
Most common presentation of molar pregnancy
Bleeding per vagina with grape like vesicles
What is the investigation of choice for molar pregnancy?
USG
Generally, blunt curettage is done after suction and evacuation in pregnancy, in which case sharpe curettage is done
Molar pregnancy
What are the risk factors during suction evacuation of molar pregnancy?
Thyrotoxicosis
Pulmonary embolism
Why oxytocin is given during suction and evacuation in molar pregnancy?
To decrease the risk of pulmonary embolism as it causes contraction of the uterus and prevents the emboli formation
Investigation of choice for follow-up of molar pregnancy
Beta HCG levels
What are the contraindications of molar pregnancy after the treatment?
1)Pregnancy is contraindicated for 6 months
2)Intra uterine devices for contraceptives are contraindicated(OCP can be used.)
p57kip2 staining is positive in which molar pregnancy, and what does it indicate
Partial mole
It indicates maternal genes
Most common gestation trophoblastic neoplasia caused by molar pregnancy
Invasive mole
Choriocarcinoma is most commonly caused by
Molar pregnancy
Most common gestational trophoblastic neoplasia caused by full term pregnancy
Choriocarcinoma
Most common sites of metastasis of gestational trophoblastic neoplasia
1st most common lungs(stage 3)
2nd most common vagina(stage 2)
If there is metastasis to lungs due to gestational trophoblastic diseases what are the chest x-ray finding?
Cannon ball appearance(most common finding)
Snowstorm appearance. (second, most common finding)
What is the name of the staging used in case of gestational trophoblastic diseases?
Figo staging
According to WHO risk scoring system for gestational trophoblastic diseases, what score is low risk and what score is high risk
Score less than or equal to 6 is low risk
Score more than or equal to 7 is high risk
At what stages, WHO scoring system is needed for giving treatment?
Stage two and three
What regimen is followed in multi drug therapy of gestational trophoblastic neoplasia?
EMACO regimen / Bagshaw regimen
E Etoposide on D1
M Methotrexate on D2
A Actinomycin D on D3
C. Cyclophosphamide on D4
O Oncovin on D5
Radiotherapy is indicated in which metastasis of gestational trophoblastic diseases
Brain metastasis
How long the follow-up is done in case of gestational trophy, plastic neoplasia, and for how long pregnancy is contraindicated?
Follow-up is done for 12 months
Pregnancy contra indicated for 12 months
Name 4 gestational trophoblastic neoplasia
Invasive mole
Choriocarcinoma
Placental site trophoblastic tumour
Epitheloid trophoblastic tumour
what are the tumour markers for placenta site trophoblastic tumour, epitheloid trophoblastic tumour?
Placental Alkaline phosphate
Human placental lactogen
