Brainscape's Knowledge GenomeTM

Browse over 1 million classes created by top students, professors, publishers, and experts.


See full index

Gynecologic Oncology > Gestational Trophoblastic Disease > Flashcards

Gestational Trophoblastic Disease Flashcards

1
Q

What proportion of GTD is non invasive or benign?

A

80%

How well did you know this?
1
Not at all
2
3
4
5
Perfectly
2
Q

Benign GTD include

A

Partial Molar pregnancy, complete molar pregnancy

How well did you know this?
1
Not at all
2
3
4
5
Perfectly
3
Q

Complete molar pregnancy has what percent chance of malignancy

A

15%

How well did you know this?
1
Not at all
2
3
4
5
Perfectly
4
Q

Partial molar pregnancy has what percent chance of malignancy

A

5%

How well did you know this?
1
Not at all
2
3
4
5
Perfectly
5
Q

Invasive GTD include

A

Invasive mole, choriocarcinoma, PSTT, ITT, Epitheliod ITT

How well did you know this?
1
Not at all
2
3
4
5
Perfectly
6
Q

Incidence rate for molar pregnancy

A

1/1500

How well did you know this?
1
Not at all
2
3
4
5
Perfectly
7
Q

Risk factors for Molar pregnancy

A

extremes of maternal age, Asian and Latina race, prior history of GTD, Deficiency in carotene, Vitamin A or animal fat, Smoking, Maternal blood type AB, A, B

How well did you know this?
1
Not at all
2
3
4
5
Perfectly
8
Q

What is the risk of recurrence with one prior molar pregnancy?

A

1%

How well did you know this?
1
Not at all
2
3
4
5
Perfectly
9
Q

What is the risk of recurrence with 2 prior molar pregnancies?

A

30%

How well did you know this?
1
Not at all
2
3
4
5
Perfectly
10
Q

Most common symptom of molar pregnancy

A

First trimester bleeding - 90%

How well did you know this?
1
Not at all
2
3
4
5
Perfectly
11
Q

Theca Lutein cysts are associated with which type of molar pregnancy?

A

complete Mole

How well did you know this?
1
Not at all
2
3
4
5
Perfectly
12
Q

Ultrasound findings for complete mole

A

no fetal parts, no amniotic fluid, thecal lutein cysts, snow storm appearance

How well did you know this?
1
Not at all
2
3
4
5
Perfectly
13
Q

Ultrasound findings for partial mole

A

Fetus with amniotic fluid, focal anechoic spaces, no thecal lutein cysts

How well did you know this?
1
Not at all
2
3
4
5
Perfectly
14
Q

True of false: Complete moles have higher HCG than partial mole?

A

True

How well did you know this?
1
Not at all
2
3
4
5
Perfectly
15
Q

Management of Complete and partial molar pregnancy

A

Suction D&C

How well did you know this?
1
Not at all
2
3
4
5
Perfectly
16
Q

Medical complications from Molar pregnancy

A

Thyroid storm, Embolization of trophoblastic tissue - RDS, Cardiac failure from high output

17
Q

risk factors associated with medical complications from Molar pregnancy

A

Uterine size > 14 - 16 wks, High HCG levels

18
Q

Presentation: Complete Mole

A

Uterus size > dates, pre-eclampsia, hyperthyroidism, theca lutein cysts

19
Q

Presentation: Partial Mole

A

Missed or complete abortion, lower HCG levels

20
Q

Risk of persistent disease and need for chemo: Complete mole

A

20%

21
Q

Risk of persistent disease and need for chemo: Partial Mole

A

5%

22
Q

Karyotype of complete mole

A 
Completely dad, 2 sperm empty ovum
46 XX (most common), 46 XY
23
Q

Karyotype of incomplete mole

A

2 sperm, complete egg

Triploidy 69 XXX or 69 XXY

24
Q

Pathology of complete mole

A

Grape like clusters, Diffuse trophoblastic proliferation

25
Q

Pathology of incomplete mole

A

fetal parts, two populations of chorionic villi, focal trophoblastic proliferation

26
Q

Risk of uterine invasion with complete mole

A

15%

27
Q

Follow up for molar pregnancy

A

weekly bHCG until 0, monthly BHCG for 6 months thereafter

28
Q

what percent of choriocarcinoma arise from complete molar pregnancies?

A

50%

29
Q

What percent of GTD cases are Placental site Trophoblastic tumors PSTT?

A

< 0.2%

30
Q

FIGO Criteria for malignant GTD after evacuation of molar pregnancy

A
  1. HCG plateau or declined < 10 % on 4 values over a 3 week period
  2. hcg increases > 10% on 3 values over a 2 week period
  3. Persistence of detectable HCG after more than 6 months following evacuation
31
Q

If a patient with GTD has evidence of vaginal involvement or evidence of metastasis on CXR what is the next step?

A

Brain CT or MRI

32
Q

What WHO score is considered Low risk

A

< 4

33
Q

What WHO score is considered middle risk

A

4 - 7

34
Q

What WHO score is considered high risk

A

> or equal to 8

35
Q

What percentage of patients with metastatic, poor prognosis disease are cure with chemotherapy

A

70%

36
Q

True or false: In patients with previous history of molar pregnancy, obtain a 6 week BHCG following next normal delivery

A

True

37
Q

Management of Choriocarcinoma

A

Multi agent Chemotherapy EMACO

38
Q

Management of placental site trophoblastic Tumors

A

Hysterectomy

Gynecologic Oncology (11 decks)

Brainscape helps you reach your goals faster, through stronger study habits.
© 2024 Bold Learning Solutions. Terms and Conditions