Benign Breast Disease and Breast Cancer Flashcards

1
Q

True or false: Breast cancer is the most common cause of female cancer in the US?

A

True

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2
Q

Breast cancer is the ____ most common cause of cancer related death in women?

A

second

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3
Q

True or false: Breast cancer is the main cause of death among women age 45 - 59

A

True

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4
Q

What is the most common breast tumor?

A

Fibroadenoma

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5
Q

At what age does ACOG recommend starting screening mammographies and at what frequency?

A

40 yrs, q 1 - 2 years

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6
Q

At what age does ACOG recommend ending screening mammographies?

A

75 yrs

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7
Q

What is the biggest risk factor in terms of relative risk for developing breast cancer?

A

Age

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8
Q

When do you start screening high risk patients

A

25 years with yearly mammogram and MRI

*BRCA and previous chest radiation

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9
Q

What does BIRADS 0 mean?

A

Need for additional imaging

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10
Q

What does BIRADS 1 mean?

A

negative, routine screening recommended

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11
Q

What does BIRADS 2 mean?

A

benign, routine screening recommended

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12
Q

What does BIRADS 3 mean?

A

probably benign, repeat mammogram in 6 months

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13
Q

What does BIRADS 4 mean?

A

Suspicious, get a biopsy

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14
Q

What does BIRADS 5 mean?

A

Highly suspicious, get a biopsy

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15
Q

What does BIRADS 6 mean?

A

Known proven biopsy, surgical excision

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16
Q

What are the most specific mammographic feature of breast cancer?

A

Spiculated mass, clustered microcalcifications

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17
Q

What is the first step in management in a patient < 30 yrs with a palpable mass?

A

Ultrasound

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18
Q

When should you biopsy a mass in a patient < 30 yrs following ultrasound?

A

If mass is solid, complex or cystic with symptoms

19
Q

What is the next step in management if you do a FNA on a cystic mass in a patient < 30 and the fluid is bloody?

A

Core biopsy or excision

20
Q

What is the first step in management in a patient > 30 yrs with a palpable mass?

A

Diagnostic mammogram

21
Q

What is the first step in management of a patient < 30 yrs with spontaneous nipple discharge?

A

Ultrasound

22
Q

What is the first step in management of a patient > 30 yrs with spontaneous nipple discharge?

A

Mammogram

23
Q

If a patient has spontaneous nipple discharge from one duct or it is bloody what is the next step in management?

A

biopsy

24
Q

Management of Lobular in situ?

A

close surveillance

25
Q

Management of ductal in situ?

A

Lumpectomy

26
Q

True or False: Lumpectomy + radiation therapy has equivalent survival rates to mastectomy

A

True

27
Q

Definition of stage I breast cancer

A

Tumor < 2 cm, negative nodes

28
Q

Definition of stage II breast cancer

A

Tumor > 2 cm but < 5 cm, positive Ipsilateral and mobile nodes

29
Q

Definition of stage III breast cancer

A

Tumor > 5 cm in greatest dimension

30
Q

Definition of stage IV breast cancer

A

Tumor of any size with direct extension to the chest wall and/or skin ulcerations with skin nodules

31
Q

When should you do adjuvant chemotherapy in a breast cancer patient?

A

Premenopausal, young, ER/PR negative, positive lymph nodes, tumor size > 1 cm

32
Q

When should you consider neoadjuvant chemotherapy

A

Large tumor size

33
Q

What is the most common type of invasive breast cancer?

A

invasive ductal carcinoma

34
Q

True or false: Ductal carcinoma occurs in younger patiensts

A

True

35
Q

What are the treatment options for ER PR positive breast cancers?

A

Tamoxifen, Aromatase inhibitors or ovarian ablation/suppression

36
Q

What are the treatment options for Her 2 receptor positive?

A

Herceptin/Trastuzamab

37
Q

What is the most common chemotherapy used to treat breastcancer?

A

Doxorubicin with Taxane

38
Q

What is a main side effect of AIs?

A

bone and joint pain, increased risk osteoporosis

39
Q

Ideal treatement regimen for SERMS and AIs?

A

5 years of SERMS then switch to AI

40
Q

What are the two main risk factors for recurrence?

A

Number of positive lymphnodes and size of tumor

41
Q

What is the most predictive factor for recurrence?

A

number of positive lymph nodes

42
Q

What is the most common location for recurrence?

A

chest wall post mastectomy

43
Q

What is the most common nodal location for recurrence?

A

Supraclavicular

44
Q

What is the median time to recurrence?

A

2-3 years