Gestational Trophoblastic Disease

Question 1

Features of complete moles

Answer 1

Diploid and androgenic origin
No evidence of fetal tissue
Usually a consequence of duplication of single sperm following ‘fertilisation of ‘empty ovum’
Some arise after dispermic fertilisation of empty ovum

Question 2

Features of partial mole

Answer 2

Usually triploid in origin, with 2 sets of paternal haploid genes & 1 set of maternal haploid genes
Occur following dispermic fertilisation of an ovum
10% represent tetraploid or mosaic conceptions
Evidence of fetus or fetal RBCs