Antenatal care for uncomplicated pregnancies, including screening+diagnosis Flashcards

1
Q

What do NICE recommend in relation to Vit D for pregnant mothers?

A

all women at booking appointment should be told of importance of maintaining adequate vit D stores during pregnancy for themselves and baby, which can be achieved with 10 micrograms per day as found in the Healthy Start multivitamin supplement.
ensure those at greatest risk are taking this supplement e.g. women of south asian, african, caribbean or middle eastern family origin, those with limited exposure to sunlight, those with diet low in meat, eggs, oily fish so low vit D intake from diet, and those with BMI more than 30 pre-pregnancy.

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2
Q

when should the booking appointment take place?

A

by 10 weeks of pregnancy, usually happens between 8 and 12 weeks, important to be this early in order to arrange screening tests-those for sickle cell and thalassaemia should be before 10 weeks.

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3
Q

what is mean by the ‘combined test’ for Downs screening, and when should this be done?

A

nuchal translucency, beta-hCG and PAPPA-pregnancy assoc. plasma protein A
to be performed between 11+0 and 13+6 weeks of gestation.

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4
Q

which women should be offered testing for gestational diabetes after their booking appointment?

A

those with any 1 of the following RFs:
BMI more than 30
gestational diabetes in previous pregnancy
previous macrosomic baby 4.5kg or greater
FH of DM (1st degree relative)
family origin with high prevalence of diabetes-south asian, black caribbean, middle eastern.

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5
Q

what is recommended pre-conceptually for those women planning a pregnancy?

A

folic acid 400 micrograms daily to reduce risk of neural tube defects (plus throughout 1st 12 weeks)
advice regarding what care will be offered during a pregnancy-all antenatal screening including risks, benefits and limitations-information should be given as soon as possible when pt 1st presents to healthcare professional
food hygience and lifestyle advice
diabetic eye screening for those with DM-offer when 1st present for care.

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6
Q

what antenatal care tests and checks should be offered at the booking appointment (ideally by 10wks)?

A
  • offer blood tests-sickle cell and thalassaemia to be done before 10 weeks. offer to check blood for Hb, group, rhesus and antibodies as early as possilbe. blood for syphilis, HIV, Hep B and rubella susceptibility as early as possible, or at any stage of the pregnancy.
  • height, weight BMI
  • BP and urine for proteinuria
  • identify those that may need additional care and plan accordingly
  • offer screening for asymptomatic bacteriuria
  • determine RFs for gestational diabetes and pre-eclampsia
  • advise those under 25yrs about high prevalence of chlamydia in this age group and give details of their local National Chlamydia Screening Programme.
  • identify women who have had genital mutilation
  • ask about mental illness or psych tment
  • ask about mood
  • ask about occupation
  • offer Downs screening
  • offer early US scan for gestational age assessment and screening for structural anomalies.
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7
Q

role of the early pregnancy ultrasound scan/dating scan (between 10 weeks and 13+6)?

A

confirm the pregnancy
gestational age-crown rump length, do head circumference if crown rump length more than 84mm.
EDD
number of gestation
viability of the pregnancy (is baby growing in the right place), and structural anomalies e.g. neural tube defects like spina bifida.

can also screen for Downs during this scan by looking at nuchal translucency IF has already been agreed for screening to take place and dating scan is occurring between 11 and 13+6 wks gestation.

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8
Q

when is an US scan for Downs screening to look at nuchal translucency able to be performed?

A

when the crown rump length is between 45 and 84mm

nuchal translucency is only visible between 11 and 13+6 weeks of gestation.

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9
Q

what is nuchal translucency?

A

refers to a collection of fluid at the back of the neck of the fetus, the size of this fluid collection denotes risk of chromosomal and other abnormalities.

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10
Q

when is the fetal anomaly scan performed?

A

between 18 and 20+6 weeks gestation

if mother’s placenta extends across internal os then offer another US at 32wks.

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11
Q

what happens in terms of downs screening if dating scan is performed after 14 weeks gestation?

A

unable to test nuchal translucency and so can’t do combination test
instead another blood test offered between 15 and 20 wks=quadruple test=beta-hCG, inhibin A, alpha fetoprotein and unconjugated oestriol.

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12
Q

what problems are being looked for specifically when performing the fetal anomaly scan?

A
anencephaly (98% chance of being seen)-die soon after birth
open spina bifida (90% chance of being seen)
cleft lip (75% chance of being seen)
diaphragmatic hernia (60% chance of being seen)
gastroschisis (98% chance of being seen)-hole in wall of baby's tummy to 1 side of umbilical cord so some of their bowel can escape through this hole onto the outside of the body and develop here.
exomphalos (omphalocele) (80% chance of being seen)-tummy fails to close around the base of the umbilical cord so some organs develop on outside of baby's tummy.
serious cardiac abnormalities (50% chance of being seen)
bilateral renal agenesis (84% chance of being seen)-die soon after birth
lethal skeletal dysplasia-baby won't survive as chest and lungs do not fully develop (60% chance of being seen)
edward's syndrome (trisomy 18) (95% chance of being seen)
patau's syndrome (trisomy 13) (95% chance of being seen)
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13
Q

things to explain in terms of what is likes to have a fetal anomaly scan?

A

usually takes around 30min, may take longer if difficult to see baby as in an awkward position or moving around a lot
recommend you bring someone with you who should accompany you to and from the hospital
doctor or midwife before appointment will let you know if full bladder required
room will be dimly lit to get best view of baby, will have to lie down on couch and lift up top and lower trousers/skirt, gel will be applied so that there is good contact between machine and your skin, probe used which emits ultrasound, may be slight pressure

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14
Q

considerations to explain to parents before a fetal anomaly scan with regards to the detection of abnormalities

A

in most cases, baby is healthy and will develop normally
some problems are obvious from the scan and we can tell you what these are, others are more difficult to detect, therefore baby may be born with an abnormality we didn’t see on the scan
if an abnormality is found a 2nd opinion may be needed, may require further tests to confirm a problem, if there is a definite problem this may just mean further scans to monitor the pregnancy as may get better on its own or may not be serious. if serious, 1 option may be terminate the pregnancy, support and advice on this will be readily available. finding a problem can help to plan treatment after birth e.g. surgery, by ensuring baby born in a hospital where there is ready access to this.

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15
Q

when is blood test for Hb and antibodies repeated?

A

at 28 weeks gestation

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16
Q

checks and info to be given at 16 weeks?

A

discuss results of screening tests
check BP and urine for proteinuria
investigate a Hb below 11 and consider iron supplements
give info on fetal anomaly scan

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17
Q

what antenatal appointment is required next after fetal anomaly scan in women who are nulliparous?

A

check at 25 weeks:
BP and urine for proteinuria
measure and plot symphysis-fundal height

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18
Q

antenatal care offered at 28weeks?

A

BP and urine for proteinuria
bloods for Hb and antibodies
investigate a Hb less than 10.5 and consider iron supplementation
offer anti-D prophylaxis (500IU) for women who are rhesus-D negative
measure and plot symphysis-fundal height
OGTT if pt at risk

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19
Q

antenatal care at 31 weeks for nulliparous women?

A

discuss screening results from 28 weeks
BP and urine for proteinuria
measure and plot symphysis-fundal height

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20
Q

antenatal care at 34 weeks?

A

discuss screening results from 28 weeks
offer 2nd dose of anti-D prophylaxis (500IU) to those who are rhesus-D negative
BP and urine for proteinuria
measure and plot symphysis-fundal height

give advice on labour and birth including pain control, birth plan and recognising active labour

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21
Q

when is external cephalic version offered?

A

this is offered at 36 weeks for those babies in breech position
at this time, also BP and urine for proteinuria, and measure and plot symphysis-fundal height.
and give info. on breast feeding, care of new baby, vit k prophylaxis and newborn screening tests, and post-natal self care includ. recognising baby blues and PN depression.

22
Q

checks after 36wks?

A

38 wks-BP, urine, symphysis-fundal height
advice on prolonged pregnancy
40 wks for nulliparous women-same, and futher advice on managing prolonged pregnancy
41 wks- offer membrane sweep
-offer labour induction
-BP, proteinuria, SF height

from 42 wks if decline labour induction offer at least twice weekly cardiotocography and US examination of max amniotic pool depth.

23
Q

what is the naegele rule?

A

this is a rule that can be used to calculate a patient’s expected date of delivery (EDD)
EDD is estimated by adding 1 year, subtracting 3 months and adding 7 days to 1st day of woman’s LMP.

24
Q

mangement of a mother exposed to VZV who is unsure about whether they have had previous chickenpox?

A

VZV presents risk to both mother and fetus in pregnancy-fetal varicella syndrome-skin scarring, micopthalmia, microcephaly, limb hypolasia, learning disability
1st step-check maternal VZV antibody status
if not immune, VZ immunoglobulin should be given-this is effective up to 10 days post exposure
if pregnant women with chickenpox present within 24hr of rash onset can give oral aciclovir.

25
Q

following what sensitising events should anti-D Ig be given?

A
amniocentesis, chorionic villus sampling
antepartum haemorrhage
abdominal trauma or fall
intrauterine death
miscarriage
EP
external cephalic version
delivery
26
Q

how is the amount of anti-D Ig to be given following a sensitising event after 20 weeks gestation determined?

A

using the feto-maternal haemorrhage test (kleihauer test): assesses how much fetal blood has entered the maternal circulation.

27
Q

initial test used antenatally to detect fetal anaemia?

A

Doppler middle cerebral artery

28
Q

what is fetal blood sampling?*

A

blood taken from fetal head in assessment of fetal distress, looking for signs of metabolic acidosis

29
Q

benefits of planned C section in an uncomplicated pregnancy and no previous C sections?

A

reduced risk of: perineal and abo pain during birth and 3 days postpartum
vaginal injury
early PPH
obstetric shock

30
Q

what indications are there for a planned C section?

A

breech presentation-singleton at term where external cephalic version has been unsuccessful or CI
twin pregnancies where 1st twin is not cephalic
placenta praevia-placenta that partly or completely covers internal cervical os
morbidly adherent placenta
those with HIV and who are not on any anti-retroviral therapy, or are receiving therapy but have viral load of 400 copies per ml or more
HIV and Hep C co-infection
primary genital HSV infection in 3rd trimester
patient choice-as long as benfits, risks and reasoning have been discussed and documented

31
Q

at what gestation should planned C sections be performed?

A

not before 39 weeks as after this time, risk of respiratory morbidity significantly decreases

32
Q

pre-operative testing before planned C section?

A

Hb and G+S, about 1week before planned C section

33
Q

what investigation should be performed after all C sections for suspected fetal compromise, to allow r/v of fetal wellbeing and guide ongoing care of the baby?

A

umbilical artery pH

34
Q

what complication are women who’ve had a previous C section at risk of if planned vaginal delivery?

A

uterine rupture

35
Q

where can fetal heart be auscultated?

A

where baby’s back in located in abdomen (smooth side)

36
Q

what measurements of growth are given on serial growth US scans?

A

abdo circumference
head circumference
femur length

37
Q

if a pregnant women is rhesus D negative, what consideration might be made before giving anti-D prophylaxis?

A

whether to offer partner testing to decide if prophylaxis is necessary

38
Q

what screening for sickle cell disease should be offered to pregnant women where disease prevalence is low?

A

family origin questionnaire-if indicates high risk offer lab screening-liquid chromatography

if women is a carrier, father must be offered counselling and appropriate screening without delay

39
Q

what choices does a fetal anomaly scan allow the parents to make?

A

termination of pregnancy
preparation for any treatment/disability/palliative care
managed birth in a specialist centre
intrauterine therapy

40
Q

antenatal screening for placenta praevia?

A

most low lying placentas detected on fetal anomaly scan will resolve by time baby is born, so only those with extension over the internal cervical os should have another transabdominal scan at 32 weeks, if this scan is unclear offer transvaginal scan.

41
Q

factors affecting accurate dating of pregnancy?

A

symphysis-fundal height assessment:
obesity
polyhydramnios
multiple gestation

42
Q

recommended mode of delivery for women who have had just 1 previous C section?

A

vaginal delivery

43
Q

what blood tests are included in the quadruple screening test for Downs (performed at 15-20 weeks gestation if too late for combined test)?

A

AFP
unconjugated oestriol
beta-hCG
inhibin A

Downs pregnancies-raised beta-hCG and inhibin A, low AFP and unconjugated oestriol

44
Q

what 2 tests must always be done at every antenatal visit?

A

BP

urine dipstick for proteinuria

45
Q

diagnostic tests available for Downs?

A

chorionic villus sampling (CVS)

amniocentesis

46
Q

when can chorionic villus sampling be offered for Downs diagnosis? what are its benefits, disadvantages and complications compared with amniocentesis?

A
  • can be offered after 10 weeks of gestation (so earlier than in amniocentesis), and results come back usually within 3 days (if rapid test done) so if termination of pregnancy decided on then can be offered early. may do chromosomal microarray which takes 2-3wks to come back.
  • cells taken form the placenta, usually transabdominal but may require transcervical approach because of uterine or placenta position. risk that cells taken from placenta have different chromosomal composition to baby (placental mosaicism)-most commonly trisomic cell line in placenta and normal diploid chromosomes in baby.
  • higher risk of miscarriage compared with amniocentesis, may be as performed earlier in pregnancy.
  • other risks-infection, limb abnormalities in baby, rhesus haemolytic disease in baby.
47
Q

when can amniocentesis be offered in pregnancy to make a genetic disorder diagnosis?

A
  • after 15 weeks of gestation (done later so that enough fluid around baby to take some without great risk to the pregnancy)
  • results take longer to come back than in CVS and as done later in pregnancy, mum may be unable to have a surgical evacuation under GA for pregnancy termination after getting her results, and would have to deliver herself.
  • however, associated with lower risk of miscarriage than CVS (amniocentesis risk is 1/100), and know that you are definitely looking at baby’s chromosomes as taking a sample of amniotic fluid which contains baby’s cells.
48
Q

why might amniocentesis be offered in pregnancy?

A
  • higher risk result obtained from Downs screening test
  • previous baby with chromosomal, genetic or other disorder
  • mum or partner has a genetic disorder or is a carrier e.g. sickle cell, thalassaemia, CF, Duchenne muscular dystrophy.
  • hx of genetic conditions in family
  • other tests during pregnancy e.g. scans, have raised the possibility of baby having a disorder
  • baby has increased risk of chromosomal disorder due to older maternal age.
49
Q

normal gestation for fetal quickening to start (start to feel baby’s movements)?

A

18-20 weeks

50
Q

how can pregnant women reduce their risk of listeriosis?

A
  • drinking only pasteurised or UHT milk
  • not eating ripened soft cheeses e.g. camembert, brie and blue veined cheese
  • no pate
  • no uncooked or undercooked ready prepared meals
51
Q

how can pregnant women reduce their risk of salmonella infection?

A

avoiding raw or partially cooked meat, especially poultry

avoiding raw or partially cooked eggs, of food that may contain them e.g. mayonnaise.