Geri GI Flashcards

1
Q

what is GERD?

A

Retrograde movement of stomach contents into esophagus secondary to transient relaxation of LES (incompetency)

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2
Q

causes of GERD?

A
  • Sliding hiatal hernia (hernia of stomach thru diaphragm)
  • Reduced LES pressure
  • Reduced pinching action of Crus of Diaphragm
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3
Q

what are factors that aggravate GERD sx’s?

A
  • Large meals
  • Fatty foods
  • Caffeine
  • ETOH/smoking
  • Obesity
  • Supine after eating
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4
Q

what are the typical sx’s of GERD?

A
  • Substernal burning with radiation to mouth/throat

- Sour tasting regurg

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5
Q

what are the atypical sx’s of GERD?

A
  • Chronic cough
  • Difficult-to-control asthma
  • Laryngitis/hoarseness
  • Recurrent chest pain
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6
Q

when is upper EGD done for dx of GERD?

A

in ALL pts w/new-onset GERD:

  • > 50 y/o
  • persistent/incomplete resolution of sx’s despite medical tx
  • hx of acid reflux >5 years
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7
Q

how do you dx pts with atypical sx’s of GERD?

A

24hr pH probe after neg work-up

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8
Q

what other causes of atypical sx’s of GERD must be r/o?

A

Inferior MI, ACS, Aortic dissection, pulmonary disease

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9
Q

what are complications of GERD?

A
  • Esophagitis
  • Esophageal ulceration
  • Bleeding
  • Strictures
  • Barrett esophagus
  • Esophageal adenocarcinoma
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10
Q

pharmacologic tx of GERD?

A

PPIs and H2 receptor blocks (Famotidine, Ranitidine) - BEST AT NIGHT

Antacid liquids or tablets (temporary)
-Mylanta, Maalox, Tums, Rolaids

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11
Q

who is surgical tx for GERD reserved for? what is the surgery?

A

pts w/severe refractory GERD w/ complications

LAPAROSCOPIC FUNDOPLICATION - wrap upper part of stomach around LES to strength the sphincter, prevent acid reflux, and repair hiatal hernia

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12
Q

what is diverticulitis?

A

inflammation d/t micro perforation of a diverticulum

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13
Q

what is the MOST COMMON sx of diverticulitis?

A

LLQ Abdominal Pain (d/t involvement of sigmoid colon)

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14
Q

what is the pain like in diverticulitis?

A

CONSTANT (present for several days prior to presentation)

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15
Q

what is complicated diverticulitis?

A

Diverticulitis with:

  • abscess
  • obstruction
  • fistula
  • perforation (have peritoneal sx’s)
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16
Q

what may DRE and stool reveal for diverticulitis?

A

DRE may reveal mass in presence of a distal sigmoid abscess

Stool may be positive for occult blood

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17
Q

labs for diverticulitis

A

serum amylase and lipase normal or mildly elevated

UA reveals sterile pyuria d/t adjacent inflammation

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18
Q

what does presence of colonic flora on Ucx for diverticulitis suggest?

A

presence of a colovesical fistula

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19
Q

what is the imaging for diverticulitis?

A

CT scan w/PO contrast

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20
Q

what will you see on CT scan w/PO contrast for diverticulitis?

A
  • Localized bowel wall thickening (>4mm)
  • Increase in soft tissue density w/in pericolonic fat secondary to inflammation or fat stranding
  • Presence of colonic diverticula
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21
Q

what are complications of diverticulitis?

A

abscesses

Bowel obstruction (dilated loops of bowel w/ air-fluid levels with pericolonic inflammation -> FAT STRANDING)

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22
Q

what is the tx of mild diverticulitis?

A

IV abx (for GN and anaerobic pathogens) until inflammation stabilized and pain/tenderness resolving (2-5 days)

Transition to PO abx (Cipro + Metro or Augmentin) for 10-14 days

Hospitalize if no improvmeent

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23
Q

tx for complicated diverticulitis?

A

surgery

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24
Q

what are the surgery indications for complicated diverticulitis?

A
  • Failed med management
  • Recurrent episodes of acute diverticulitis
  • Peritonitis
  • Failed percutaneous drainage of abscess
  • Enterocutaneous fistula formation
  • Bowel obstruction
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25
Q

what is the definition of constipation? seen in who?

A

Infrequent and/or unsatisfactory defecation < 3 times/week

> 65 y/o women

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26
Q

how long must sx’s of constipation be present for dx of CHRONIC constipation?

A

presence of sx’s for at least 12 weeks

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27
Q

is constipation a disease?

A

NO!!! IT’S A SYMPTOM

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28
Q

what are causes of constipation?

A

Changes in neuromuscular control of colon predispose to constipation (may occur with bed rest or constipating meds)

Passing hard stools or straining, incomplete or painful defecation

Hypothyroidism, Colon Cancer

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29
Q

disorders that are risk factors for constipation?

A
  • Malignancy (colon ca)
  • Endocrine/metabolic (DM, hypothyroidism, hypercalcemia, hypokalemia)
  • Neuro d/o (Parkinson’s, diabetic autonomic neuropathy, spinal cord injury, dementia, stroke)
  • Rheumatologic d/o (systemic sclerosis and other connective tissue d/o)
  • Psych d/o (depression or eating d/o)
  • Anatomic dysfxn (strictures, postsurgical abnormalities, anal fissures, megacolon, hemorrhoids
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30
Q

what are general risk factors for constipation?

A
  • Female, >65 y/o
  • Low caloric intake
  • ***Polypharmacy
  • Sedentary lifestyle
  • Ignoring urge to defecate/chronic fecal retention
  • Abnormal responses of the pelvic floor muscles during defecation
  • Blunted rectal sensation
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31
Q

sx’s of constipation?

A

Bloating, fullness, and incomplete evacuation

Infrequent defecation, difficulty passing stool

32
Q

what are ALARM SX’S of constipation?

A
  • Hematochezia
  • Fam hx of colon ca/IBD
  • Anemia
  • Pos. fecal occult blood test
  • Unexplained weight loss >10lbs
  • Constipation refractory to tx
  • New-onset constipation w/out evidence of potential primary cause
33
Q

what do you evaluate to dx constipation?

A
  • Duration of sx’s
  • Freq/consistency of stools
  • Presence of excessive straining
  • Feeling of incomplete evacuation
  • Use of manual maneuvers during defecation
  • Potential organic causes or drug rxn
34
Q

Abdominal X-ray showing significant stool retention in colon suggests dx of what?

A

megacolon

35
Q

if pt has alarm sx’s of constipation, what imaging should be done promptly?

A

abd CT

36
Q

if pt with constipation is stable, how do you evaluate them?

A

with colonoscopy

37
Q

what studies are used in pts w/infrequent defecation?

A

Marker studies/colonic transit studies

38
Q

tx for pts with constipation and normal colonic transit time?

A
  • Fluids, Dietary fibers (recommended 20-35g/day)
  • Pts who don’t tolerate fiber require laxatives
  • Stimulant laxatives: bisacodyl and senna
  • Stool softener: Colace

Softeneruppers

39
Q

what are the Softeneruppers?

A

Bulk agents: psyllium, methylcellulose, calcium polycarbophil, wheat dextrin

Nonabsorbed substances: PEG 3350, lactulose, MG salts

40
Q

tx for pts with constipation and slow colonic transit time?

A

Osmotic laxatives, sorbitol, lactulose or polyethylene glycol

Probiotics may promote colonic mucosal health

Moveralongers

  • stimulants: bisacodyl, Senna
  • secretory drugs: lubiprostone, linaclotide
41
Q

when is disimpaction done for tx of constipation?

A

before polyethylene glycol solution and/or enemas

42
Q

maintenance for tx of constipation?

A
  • Scheduled toileting after breakfast
  • Add fiber supplements to regulate bowel havits and prevent constipation
  • Regular use of a stimulant laxative such as senna or Dulcolax
43
Q

what is the definition of diarrhea? based up presence of what?

A

Decr in fecal consistency lasting >4wks

Based upon presence of excessive stool freq

44
Q

what is the cause of ACUTE diarrhea?

A

Infectious cause

-C. diff colitis

45
Q

what are the causes of CHRONIC diarrhea?

A
  • Fecal impaction
  • IBS
  • IBC (CD, UC)
  • Malabsorption syndromes
  • Chronic infections
  • Colon CA
46
Q

what are sx’s of diarrhea?

A
  • recent weight loss
  • bloating or gas (celiac disease/small bowel overgrowth)
  • recent abx use/hospitalization (C. diff)
  • mouth ulcers, skin rash, anal tissue or fistula (IBD)
  • malabsorption (wasting, anemia, scars, from prior abd surgery)
  • lymphadenopathy (infection)-a
  • abnormal anal sphincter pressure/reflexes (fecal incontinence)
47
Q

dx of acute diarrhea

A

stool cx to exclude infection (usually viral like rotavirus and Norwalk)

C. diff toxin assay (toxin A and toxin B) -> only if recent abx use

48
Q

dx of chronic diarrhea

A

Colonoscopy in pts w/hx of weight loss, bloody diarrhea, and diarrhea lasting >4 weeks

Breath hydrogen/methane test in pts suspected to have small bowel bacterial overgrowth (confirms early fermentation of ingested sugars in small bowel)

Qualitative or quantitative stool fat for steatorrhea

TSH

49
Q

how do you treat diarrhea if no acute infection/no blood in stool?

A

Loperamide or Bismuth subsalicylate

50
Q

what meds should be avoided in C. diff colitis and why?

A

***Antidiarrheal agents should be avoided in C. diff colitis b/c of risk of precipitating ileus and megacolon

51
Q

careful with what agents in elderly for diarrhea?

A

anti motility agents (ex: Lomotil) b/c has cholinergic effect

52
Q

tx for diarrhea w/ mild small bowel overgrowth?

A

bismuth-containing meds

53
Q

tx for diarrhea w/ severe small bowel overgrowth?

A

Cipro

Neomycin, Rifaxamin for 14-21 days

54
Q

what is the definition of fecal incontinence?

A

Continuous/recurrent uncontrolled passage of fecal material for at least 1 month

55
Q

what is the 2nd leading cause of nursing home placement?

A

fecal incontinence

50% in SNF pts

56
Q

what are some contributing factors to fecal incontinence?

A
  • dysfxn of internal or external anorectal sphincters
  • pudendal nerve injury
  • rectal prolpase
  • immobility
57
Q

what are the 4 types of fecal incontinence

A

(1) Passive incontinence
(2) Urgency incontinence
(3) Acute
(4) Intermittent incontinence

58
Q

what is Passive fecal incontinence?

A

leakage of small quantities of liquid or solid stool w/out awareness

59
Q

what is Urgency incontinence?

A

frequent urge to defecate, followed by passage of small quantities of liquid stool w/or w/out mucus or blood

60
Q

what is Acute fecal incontinence?

A

diarrhea

61
Q

what is Intermittent fecal incontinence?

A

in pts with dementia, delirium, pelvic floor denervation, or excessive laxative use

62
Q

what are some sx’s of fecal incontinence?

A

abd tenderness, bloating, distention, presence of hard stool in rectal vault (all may indicate fecal impaction)

rectal prolapse or proposing hemorrhoids

Dementia/delirium based on MS exam (loss of self-toileting)

Absence of anal sphincter tone/wink (denervation of pudendal nerve from spinal cord lesion)

63
Q

what does absence of anal sphincter tone/wink mean?

A

denervation of pudendal nerve from spinal cord lesion

64
Q

dx of fecal incontinence

A

DRE (detects sphincter tone or presence of mass)

Abd plain film (fecal impaction)

Abd X-ray or CT (high impactions)

Spinal MRI (acute onset passive incontinence to r/o cord compression)

COLONOSCOPY (mechanical cause)

65
Q

tx of fecal incontinence?

A

Disimpaction, bowel cleansing, hydrate, move more, no constipating meds, scheduled toiling after breakfast

66
Q

where do hemorrhoids arise from?

A

Arise from plexus of dilated arteriovenous channels/cushion and connective tissue

67
Q

why are external hemorrhoids painful?

A

contain somatic pain receptors and can thrombose

68
Q

most hemorrhoids are what for sx’s?

A

asymptomatic

69
Q

sx’s of symptomatic hemorrhoids?

A
  • Hematochezia
  • Pain
  • Perianal pruritus
  • Fecal soilage
70
Q

MOST COMMON sx’s of hemorrhoids?

A

irritation/itching of perianal skin

PAINLESS BLEEDING associated w/BM (BRB)

71
Q

how do you dx hemorrhoids?

A

Anoscopy or DRE ore just look

  • BRBPR
  • eval anal canal and distal rectum
72
Q

when do you suspect thromboses hemorrhoid?

A

when hemorrhoids not detected on DRE

73
Q

when do you do Flex sig or colonoscopy evaluation for hemorrhoids?

A

Flex sig or colonoscopy in pts >40 y/o, based on presence of associated sx’s and RF’s for colorectal cancer

74
Q

what are the 4 grades of internal hemorrhoids?

A

Grade 1: see on anoscopy, bulges into lumen, but no prolapse

Grade 2: prolapses with defecation/straining but reduce spontaneously

Grade 3: prolapse out of anal canal with defecation/straining, but require manual reduction

Grade 4: irreducible and may strangulate

75
Q

what is the tx of hemorrhoids?

A

fiber (psyllium or methylcellulose)

analgesics (topical ointments elective for relieving acute pain)

venoactive agents

antispasmodic agents (top .5% Nitro ointment to reduce internal anal sphincter spasm)

76
Q

what is the surgery for bleeding internal hemorrhoids? what is not treated with this surgery? can also do what tx?

A
  • **Rubber band ligation
  • External tags and ext. hemorrhoids NOT treated with this

can also do Sclerotherapy