Geral 1

Question 1

Dose de morfina na raqui?
gonvers = revista anestesia 2022

Answer 1

In conclusion, there is good evidence that intrathecal morphine provides effective analgesia after lower limb arthroplasty, without an increased risk of respiratory depression, but at the expense of an increased rate of postoperative nausea and vomiting. A dose of 100 ug is a ‘ceiling’ dose

Question 2

Mecanismo da hipertermia maligna

Answer 2

Mechanism. Exposure to triggering anesthetics causes decreased control of intracellular calcium, resulting in excessive release of free unbound ionized Ca2+ from storage sites. The calcium pumps attempt to restore homeostasis, which results in increased adenosine triphosphate utilization, increased aerobic and anaerobic metabolism, and a runaway hypermetabolic state. Rigidity occurs when unbound myofibrillar Ca2+ approaches the contractile threshold, when it cannot be removed due to overwhelmed calcium pumps