GENPATH Cancer (2) Effects of Cancer

Question 1

Give 3 example of Paraneoplastic syndromes associated with lung cancer

[…]

Answer 1

***1. Cushing Syndrome - Excess ACTH
2. SIADH - Excess ADH (or ANP)
3. Hypercalcemia (excess PTH)
4. Myasthenia gravis (immunological)

Question 2

In Familial adenomatous polyposis (FAP), there is 100% risk of […] cancer without intervention

Answer 2

In Familial adenomatous polyposis (FAP), there is 100% risk of colon cancer without intervention

Recall that FAP is APC gene.

Question 3

Local effects of tumor on hosts

On vessels - […]
On epithelial surfaces - […]
On nervous system - […]
On ducts - […]

Answer 3

Local effects of tumor on hosts

On vessels - Haemorrhage, inflammation, Edema
On epithelial surfaces - ulcer
On nervous system - Pain, Seizure, Cerebral Dysfunction, loss of sensory or motor function
On ducts -* bleeding, perforation, obstruction*

Symptoms are dependent on the nature of the cancer! Origin, behaviour, e

Question 4

Paraneoplastic Syndromes = symptom complexes in cancer patient not attributable to […] or […]

Answer 4

Paraneoplastic Syndromes = symptom complexes in cancer patient not attributable to local or distant spread of the tumour or* hormonal effects indigenous to the tissue from which the tumour arose*

Defining this was worth 4 marks in one of the years. WOW. The definition