Genitourinary Diseases Flashcards
Afferent arterioles
enter the glomerulus
Efferent arterioles
leave the glomerulus
Endothelial cells
line the arterioles
Pseudofenestrations
holes in the endothelials cells that line the arterioles
Glomerular basement membrane
located on top of the endothelial cells and below the visceral epithelial cells.
parietal epithelial cells
once the endothelial cells are in Bowman’s capsule
Juxtaglomerular Cells
control blood pressure
Mesangial cells
in the middle of arterioles
contract
heal the glomeruli
Monocytes are found here
Juxaglomeruli apparatus
Decrease BP in afferent arterioles
Decrease glomerular filtration rate
Glomerulonephritis
inflammation of the kidney parenchyma
Circulating immune Complex Glomerulonephritis
SPECIFIC, immune complexes form OUTSIDE the kidney in the subintimal space
TYPE III Hypersensitivity reaction
Antigenic Glomerulonephritis
formation of ANTIBODIES against ANTIGENS of the basement membrane
TYPE II Hypersensitivity reaction (Compliment dependent)
Formation of Immune complex WITHIN the kidneys
Heymann Glomerulonephritis
ANTIBODIES against visceral epithelial cells / Podocytes
Production of antibodies AGAINST hidden antigens
Permiability of Glomeruli
Water ONLY, not permeable to blood cells or protein
Nephritic Syndrome
hematuria
Oliguria / Azotemia
Uremia
Azotemia
a biochemical abnormality that refers to an elevation of BUN and creatinine
Uremia
azotemia + clinical signs and symptoms
MORE SERIOUS
Acute Proliferative Poststreptococcal Post Infectious Glomerulonephritis
CHILDREN Enlarged tonsils w/ white spots Antibodies against antigens Streptococcal wall Beta Hemolytic Strep A group Hematuria Azotemia Proteinuria Hypertension Molecular Mimicry
Molecular Mimicry
confusion of antibodies that bind to normal active tissue instead of the pathogen
Type II or Type III Hypersensitivity Reaction
Rapid Progressive Crescentic Glomerulonephritis
rapid & progressive loss of renal function
