GENITOURINARY Flashcards
1
Q
Features of Leydig Cell tumour
A
- Most common of the sex cord-stromal tumours
- Benign behaviour
- Micro:
Diffuse (most common), lobular, insular, tubular, pseudofollicular patterns
Large, round or polygonal cells with well defined borders, eosinophilic or vacuolated cytoplasm
Round/ovoid nuclei with prominent nucleoli
-IHC: inhibin and calretinin +
Negative for germ cell tumour markers
2
Q
Features of Spermatogenic tumour
A
- Unrelated to germ cell neoplasia in situ
- Older men
- Micro:
Diffuse growth with scant fibrous or oedematous stroma.
Polymorphous cell population: small Lo-like cells, intermediate cells and giant cells. - IHC: Negative for most germ cell-associated markers (OCT3/4, D240, PLAP, AFP, HCG & CD30)
Positive for SALL4 & CD117