ENDOCRINE

Question 1

Classification of neuroendocrine neoplasms (WHO 2010)

gastrointestinal and pancreatic

Answer 1

• NET G1 (carcinoid): <2mitosis/10HPF and/or Ki67 index<2%
• NET G2: 2-20mitosis/10HPF and/or Ki67 index
  3-20%
• NEC (large cell or small cell type) >20mitosis/10HPF &/or Ki67 index >20%
• Mixed Adenoneuroendocrine carcinoma (MANEC)
• Hyperplastic and preneoplastic lesions
  Note: Grading requires mitotic count in at least 50 HPF (1 HPF=2mm). Ki67 index using the MIB Ab as a percentage of 500-2000 cells counted in hot spot areas (areas of strongest nuclear labelling). If mitotic count and Ki67 differ, use the highest grade