Genitourinary 2 Flashcards
What leads to nonfunctional testes?
lack of descent of testes into scrotum
When does the descent begin? When does the testes really start to move?
7 mos. of gestation
Where does the testes migrate down through and what is it guided by during its descent?
migrates through inguinal ring into scrotum, guided by gubernaculum
cryptorchidism
no descent into scrotum; maldescent of testes
percent of testes migration fails; arrested somewhere along the route
4%
where is the most common location where the testes arrests during maldescent?
inguinal ring/canal
What percent is the maldescent of testes unilateral (just one testes fails to descend)?
75%
What causes maldescent of testes?
genetic + environmental factors
Atrophy and sterility are common if testes don’t descend, unless it is corrected by what age?
age 2
even after surgical correction, greatly increased incidence of germ cell tumors (seminoma + embryonal carcinoma)
orchitis
infection of the testes
- if bilateral, may result in sterility
- often associated with infection from epididymis (epididymitis)
3 testes infections + a rare one
- acute bacterial epididymoorchitis
- viral orchitis
- TB epididymorchitis
- tertiary syphilis- rare, gumma formation
viral orchitis
forms mumps, occurs after puberty
-if bilateral after puberty, infertility and sterility possible
testicular tumors
high proportion seen in early adult life (20-45 years)
2 groups of testicular tumors
1 germ cell
2 sex cord stromal tumors
germ cell testicular tumors
malignant, 97 % more common, derived from multipotential germ cells of testes
sex cord stromal testicular tumors
3% of tumors, benign, from specialized support cells of testis