Genitalia

Question 1

Intermediate Mesoderm becomes..

Answer 1

Reproductive Organs

Question 2

Endodermally derived yolk sac becomes..

Answer 2

sperm and eggs

Question 3

Indifferent Gonads

Answer 3

5-7 weeks
germ cells from yolk sac
thickening of medial meonephros to from genital ridge

Question 4

Migration of germ Cells along dorsal Mesentery

Answer 4

Week 4

Question 5

Germ cells into primary sex cords

Answer 5

Week 6

Question 6

Gonadal Ridge

Answer 6

From proliferating epithelium and mesenchyme

Question 7

Gonad

Answer 7

external cortex, internal medulla

Question 8

Sex Determination

Answer 8

Week 7

SRY gene in Y chromosome to produce TDF

Question 9

Testes From Sex cords?

Answer 9

sex cords&raquo_space; Seminiferous cords&raquo_space; tubules&raquo_space; rete testes

Question 10

Interstitial Cells of Leydig

Answer 10

adjacent to seminiferous tubules, produce testosterone

Week 8

Question 11

Sertoli Cells

Answer 11

Part of Sem tubule, produce sperm, suppress mullein ducts (AMH)
MIS inhibits parames ducts

Question 12

Mesonephric tubules in Males

Answer 12

Ree Testis

Question 13

Mesonephric Duct in Males

Answer 13

Efferent Ductules, Ductus Epididymis, Ductus Deferens

Wolffian Ducts

Question 14

Paramesonephric Ducts

Answer 14

Mullerian Ducts

Question 15

Seminal Vesicle

Answer 15

along the ejaculatory duct, nourished the sperm

Question 16

Prostate Derivation

Answer 16

Endodermal outgrowths surrounding mesenchyme

Transports sperm while giving it fluid for semen

Question 17

Bulbourethral Glands

Answer 17

outgrowths of spongy urethra

contribute to semen

Question 18

Paramesonephric ducts

Answer 18

develop lateral to gonads and mesonephric ducts

pass caudally, meet as Y uterovaginal primordium

Question 19

Mullerian Sinus/Tubercle

Answer 19

Projection of utervaginal primordial into urogenital sinus

Question 20

Urethral Plate and Urogenital Folds

Answer 20

Folds around endodermal cells to form longitudinal penile raphe

Question 21

Glandular Plate

Answer 21

Ectodermal infolding in Glans to canalize spongy urethra

Question 22

Foreskin

Answer 22

Prepuce ectodermal outgrowth cleft at 12th week

Question 23

Muscles of Penis

Answer 23

corpora cavernosa and corpus spongiosum

Question 24

Scrotum

Answer 24

fusion of the labioscrotal swelling

Question 25

Female Urogenital Folds

Answer 25

fuse caudally, cranially, not in middle >> labia minora

Question 26

Unfused labioscrotal folds >>

Answer 26

labia majora

Question 27

``` Homologue from Female: Prostatic Utricle Prostate Bulbourethral Gland Ventral penis Scrotum ```

Answer 27

``` Homologue from Male: Vagina Urethral Glands Bartholins Labia minora (UG Fold) Labia majora (LS Fold) ```

Question 28

Disorders of Sexual Development

Answer 28

errors in sex determination and differentiation

Question 29

Congenital Adrenal Hyperplasia

Answer 29

46XX with ambiguous genitalia Rx prenatally with steroids until gender determined

Question 30

46XY with ambiguous genitalia

Answer 30

inadequate production of testosterone and MIS by fetal testes

Question 31

Androgen Insensitivity Syndrome

Answer 31

46XY Defect in androgen receptor, but normal appearance blind-ending vagina and rudimentary/absent uterus

Question 32

Hypospadias

Answer 32

inadequate production of androgens and/or inadequate receptors failure of ectodermal cord canalization failure of fusion of urogenital folds for incomplete formation of spongy urethra

Question 33

Agenesis of External Genitalia

Answer 33

failure of genital tubercle to develop

Question 34

Anomalies of Uterus/Vagina

Answer 34

Incomplete parameonephric duct fusion incomplete development of paramesonephric duct incomplete canalization of the vaginal plate

Question 35

Uterus Didelphy

Answer 35

Failure of fusion in inferior paramesonephric

Question 36

Bicornuate Uterus/ Unicornuate

Answer 36

only superior part of body of uterus only one forms

Question 37

Septate Uterus

Answer 37

abnormal fusion with internal septum

Question 38

absence of vagina and uterus

Answer 38

Failure of sinovaginal bulbs to develop and form vaginal plate

Question 39

Vaginal Atresia

Answer 39

failure of canalization of vaginal plate

Question 40

Gubernaculum

Answer 40

ligament from gonad through abdominal wall and into labioscrotal folds A PATH!

Question 41

Descent of the Testicle

Answer 41

1) enlarged testes and atrophy of mesonephric kidneys 2) atrophy of parames ducts enable movement to deep inguina, 3) processus vaginalis guides through inguinal canal into scrotum 26 wks via testosterone and increased intra-abdominal pressure

Question 42

Hydrocele

Answer 42

Abdominal end of Processus Vaginalis has small opening allowing peritoneal fluid to pass through

Question 43

Vaginal Development

Answer 43

develops through vaginal plate derived from urogenitall sinus

Question 44

Most common anomalies in female genital tract

Answer 44

incomplete fusion of paramesonephric ducts