Female Repro Microstructure Flashcards
Eggs per Month
20-50 recruited/ month to develop. Secondary follicles dependent upon FSH for development
Ovary Blood Supply
Mesovarium blood vessels in mid medulla
tunica albuginea
surrounds the ovary
Follicle development at late primary follicle
follicular cells»_space; granulosa cells
ooocyte forms, surrounded by z pellucida, theca interna
Secondary/Antral Follicle
theca externa/interna, antrum forming, granulosa cells
Mature/Graafian Follicle
Theca externa/interna, ring of granulosa cells surround liquor follicle, corona radiata, cumulus oophorus
Appearance of Primary Oocyte
larger, cuboidal granulosa cell
Components of Zona Pellucida
glycoprotein and acid proteoglycans
ZP1, 2, 3
What’s in an antrum
liquor follicule (FSH, Estrogen)
Secondary Follicle components
theca externa: fibroud
granulosa interrupted by antrum
Purpose of antrum
steroids, pituitary hormones, local growth factors
Appearance of graafian
antrum enlarges and the oocyte is displaced
granulosa cells surround oocyte
What surrounds Oocyte in Graafian
Corona radiata Cumulus Ooopohorus
Early Stage of oocyte from follicle: antrum
mucoplysacchrides depolymerize and increase colloid osmotic pressure.
granulosa less cohesive and cumulus loosens
Where does follicle break down
stigma
Role of LH pre ovulation
stimulate granulosa to produce plasminogen activator and cause plasmin.
follicle wall ruptures
Role of LH post ovulation
cause granulosa cells to transform into gran lutein and theca intern into theca lutein
Corpus Lutein!
Corpus Luteum
secrete progesterone and estrogen.
Enlarges if implantation occurs,
Granulosa Lutein
Progesterone produceers
Theca Lutein
Estrogen precursors
Follicle Atresia
dying follicle
Role of Estrogen
- promote development and maintenance of reproductive structures
- increase protein metabolism
- lower cholesterol
- inhibit GnRH, FSH, LH
Role of Progesterone
- prep endometrium for implantation
- prep breasts to secrete milk
- inhibit GnRH and LH
Oviduct Functions
- transport germ cells
- capacitation and fertilization
- transport zygote
Ampulla anatomy
- many mucosal folds into lumen
- mucus membrane with epithelium and lamina propria
Oviduct Cell types
1) ciliated: aid transport of sperm up isthmus
2) non-ciliates secretory cells
3) SM muscle coat for peristalsis
Epithelium of Endometrium
pseudostratified ciliates and some w/ microvilli
Layers of Endometrium
Stratum Functionalis (shed)
Stratum Basalis
Myometrium
Cycles of Menstral Period
Proliferative-endo regenerates
Secretory- endo thickens
Ischemic- drop in hormones
Menstrual- functional layer GONE
Arterial Supply to Endometrium
Uterine artery in myometirum
upward branches spiral and form capillary beds at functional is surface
When is the Late Secretory Phase
Days 15-28
Endocervix cell type
simple columnar mucus-secreting cells
Phases of mucus secretion
Around ovulation: thin and watery (estrogen)
After ovulation: viscous (progesterone)
95% cervical cancers occur where
in squamo-columanr junction zone of cervix (low pH and squamous metaplasia healing leaves it susceptible to virus)
Vagina cells
- stratified squamous epithelium
- NO GLANDS
- fibroelastic lamina propria
- layer of circular SM
- skeletal muscle at orifice
Vaginal Exctretion?
synthesizes glycogen in response to estrogen (lactic acid after bacteria..)
Breast Tissue change at pregnancy
inactive ducts proliferate into alveoli at ends of ducts, fully differentiate and secrete milk
Hormones of breast change
estrogen, progesterone, lactogenic hormones
Breast Protein release
via exocytosis of merocrine secretion. lipids discharged via apocrine
